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[Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino].
Yao Xue Xue Bao. 2002 Apr; 37(4):267-70.YX

Abstract

AIM

To investigate the water-soluble steroidal saponins in total saponin from Dioscorea nipponica Makino and look for new active compounds.

METHODS

The compounds were isolated with silica gel, PTLC and HPLC, and their structures were elucidated by acid hydrolysis, physical and chemical data and spectral analysis (IR, NMR, MS, HMQC, HMBC) as well as chemical correlations.

RESULTS

The two steroidal saponins (water-insoluble saponin and water-soluble saponin) were isolated from the total saponin of Dioscorea nipponica Makino. The structures were elucidated as diosgenin 3-O-[alpha-L-rhamnopy ranosyl (1-->2)-[beta-D-glucopyranosyl(1-->3)]]-beta-D-glucopyranoside (I), diosgenin 3-O-[alpha-L-rhamnopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl (1-->4)]-beta-D-glucopyranoside (II).

CONCLUSION

Compound II is a new steroidal saponin and firstly isolated from Dioscorea nipponica Makino. It was named as dioscin Dc.

Authors+Show Affiliations

Du SH
Anhui Institute of Medical Sciences, Hefei 230061, China. dushuhu@ah163.com
Liu WY
No affiliation info available
Fu TJ
No affiliation info available
Xia BG
No affiliation info available
Xia CD
No affiliation info available

MeSH

DioscoreaMolecular ConformationMolecular StructurePlants, MedicinalRhizomeSaponins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12579821

Citation

Du, Shu-hu, et al. "[Isolation and Identification of Steroidal Saponins in Total Saponin From Dioscorea Nipponica Makino]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 37, no. 4, 2002, pp. 267-70.
Du SH, Liu WY, Fu TJ, et al. [Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino]. Yao Xue Xue Bao. 2002;37(4):267-70.
Du, S. H., Liu, W. Y., Fu, T. J., Xia, B. G., & Xia, C. D. (2002). [Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 37(4), 267-70.
Du SH, et al. [Isolation and Identification of Steroidal Saponins in Total Saponin From Dioscorea Nipponica Makino]. Yao Xue Xue Bao. 2002;37(4):267-70. PubMed PMID: 12579821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino]. AU - Du,Shu-hu, AU - Liu,Wen-ying, AU - Fu,Tie-jun, AU - Xia,Bo-gang, AU - Xia,Chong-dao, PY - 2003/2/13/pubmed PY - 2003/12/10/medline PY - 2003/2/13/entrez SP - 267 EP - 70 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 37 IS - 4 N2 - AIM: To investigate the water-soluble steroidal saponins in total saponin from Dioscorea nipponica Makino and look for new active compounds. METHODS: The compounds were isolated with silica gel, PTLC and HPLC, and their structures were elucidated by acid hydrolysis, physical and chemical data and spectral analysis (IR, NMR, MS, HMQC, HMBC) as well as chemical correlations. RESULTS: The two steroidal saponins (water-insoluble saponin and water-soluble saponin) were isolated from the total saponin of Dioscorea nipponica Makino. The structures were elucidated as diosgenin 3-O-[alpha-L-rhamnopy ranosyl (1-->2)-[beta-D-glucopyranosyl(1-->3)]]-beta-D-glucopyranoside (I), diosgenin 3-O-[alpha-L-rhamnopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl (1-->4)]-beta-D-glucopyranoside (II). CONCLUSION: Compound II is a new steroidal saponin and firstly isolated from Dioscorea nipponica Makino. It was named as dioscin Dc. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/12579821/[Isolation_and_identification_of_steroidal_saponins_in_total_saponin_from_Dioscorea_nipponica_Makino]_ DB - PRIME DP - Unbound Medicine ER -