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[Isolation and identification of steroidal saponins from Dioscorea panthaica Prain et Burkill].
Yao Xue Xue Bao. 2001 Jan; 36(1):42-5.YX

Abstract

AIM

To investigate the chemical constituents of the rhizomes of Dioscorea panthaica Prain et Burkill and look for new active compounds.

METHODS

The compounds were isolated with silica gel and HPLC, and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, ESI-MS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HMQC, HMBC, NOESY).

RESULTS

Three steroidal saponins were isolated from the rhizomes of Dioscorea panthaica. They were elucidated as 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-23(S)-methoxy-25(R)-delta 5,20(22)-diene-furosta-3-O-[alpha-L-rhamnopyranosyl-(1-->2)- O-alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside (I), pseudoprotodioscin (II), 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-25 (R)-delta 5,20(22)-diene-furosta-3-O-alpha-L-rhamnopyranosyl- (1-->2)-O-beta-D-glucopyranoside (III).

CONCLUSION

Compound I is a new steroidal saponin and was named as dioscoreside C. Compound II and III were obtained from this genus for the first time.

Authors+Show Affiliations

Dong M
Department of Natural Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110015, China.
Wu LJ
No affiliation info available
Chen Q
No affiliation info available
Wang BX
No affiliation info available

MeSH

DioscoreaMolecular ConformationMolecular StructurePlants, MedicinalRhizomeSaponinsSteroids

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12579859

Citation

Dong, M, et al. "[Isolation and Identification of Steroidal Saponins From Dioscorea Panthaica Prain Et Burkill]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 36, no. 1, 2001, pp. 42-5.
Dong M, Wu LJ, Chen Q, et al. [Isolation and identification of steroidal saponins from Dioscorea panthaica Prain et Burkill]. Yao Xue Xue Bao. 2001;36(1):42-5.
Dong, M., Wu, L. J., Chen, Q., & Wang, B. X. (2001). [Isolation and identification of steroidal saponins from Dioscorea panthaica Prain et Burkill]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 36(1), 42-5.
Dong M, et al. [Isolation and Identification of Steroidal Saponins From Dioscorea Panthaica Prain Et Burkill]. Yao Xue Xue Bao. 2001;36(1):42-5. PubMed PMID: 12579859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Isolation and identification of steroidal saponins from Dioscorea panthaica Prain et Burkill]. AU - Dong,M, AU - Wu,L J, AU - Chen,Q, AU - Wang,B X, PY - 2003/2/13/pubmed PY - 2003/8/9/medline PY - 2003/2/13/entrez SP - 42 EP - 5 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 36 IS - 1 N2 - AIM: To investigate the chemical constituents of the rhizomes of Dioscorea panthaica Prain et Burkill and look for new active compounds. METHODS: The compounds were isolated with silica gel and HPLC, and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, ESI-MS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HMQC, HMBC, NOESY). RESULTS: Three steroidal saponins were isolated from the rhizomes of Dioscorea panthaica. They were elucidated as 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-23(S)-methoxy-25(R)-delta 5,20(22)-diene-furosta-3-O-[alpha-L-rhamnopyranosyl-(1-->2)- O-alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside (I), pseudoprotodioscin (II), 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-25 (R)-delta 5,20(22)-diene-furosta-3-O-alpha-L-rhamnopyranosyl- (1-->2)-O-beta-D-glucopyranoside (III). CONCLUSION: Compound I is a new steroidal saponin and was named as dioscoreside C. Compound II and III were obtained from this genus for the first time. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/12579859/[Isolation_and_identification_of_steroidal_saponins_from_Dioscorea_panthaica_Prain_et_Burkill]_ DB - PRIME DP - Unbound Medicine ER -