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Antioxidant vitamin intake and risk of Alzheimer disease.
Arch Neurol. 2003 Feb; 60(2):203-8.AN

Abstract

BACKGROUND

The generation of oxygen free radicals is involved in the pathogenesis of Alzheimer disease (AD).

OBJECTIVE

To determine whether the intake of antioxidant vitamins decreases the risk of AD.

METHODS

We investigated the relationship between AD and the intake of carotenes, vitamin C, and vitamin E in 980 elderly subjects in the Washington Heights-Inwood Columbia Aging Project who were free of dementia at baseline and were followed for a mean time of 4 years. Semiquantitative food frequency questionnaires were administered between baseline and the first follow-up visit. Cox proportional hazards regression models were conducted with quartiles of each vitamin intake as the exposure of interest and incident AD as the outcome, adjusted for age, level of education, sex, APOE epsilon4 status, ethnicity, and smoking.

RESULTS

There were 242 incident cases of AD in 4,023 person-years of follow-up (6 per 100 person-years). Intake of carotenes and vitamin C, or vitamin E in supplemental or dietary (nonsupplemental) form or in both forms, was not related to a decreased risk of AD. Trend tests for the association between quartiles of total intake of vitamins C and E also were not significant.

CONCLUSION

Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study.

Authors+Show Affiliations

Luchsinger JA
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY, USA.
Tang MX
No affiliation info available
Shea S
No affiliation info available
Mayeux R
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseAntioxidantsAscorbic AcidCarotenoidsCohort StudiesDietDietary SupplementsFemaleHumansIncidenceMaleRisk FactorsVitamin E

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12580704

Citation

Luchsinger, Jose A., et al. "Antioxidant Vitamin Intake and Risk of Alzheimer Disease." Archives of Neurology, vol. 60, no. 2, 2003, pp. 203-8.
Luchsinger JA, Tang MX, Shea S, et al. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol. 2003;60(2):203-8.
Luchsinger, J. A., Tang, M. X., Shea, S., & Mayeux, R. (2003). Antioxidant vitamin intake and risk of Alzheimer disease. Archives of Neurology, 60(2), 203-8.
Luchsinger JA, et al. Antioxidant Vitamin Intake and Risk of Alzheimer Disease. Arch Neurol. 2003;60(2):203-8. PubMed PMID: 12580704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant vitamin intake and risk of Alzheimer disease. AU - Luchsinger,Jose A, AU - Tang,Ming-Xin, AU - Shea,Steven, AU - Mayeux,Richard, PY - 2003/2/13/pubmed PY - 2003/3/12/medline PY - 2003/2/13/entrez SP - 203 EP - 8 JF - Archives of neurology JO - Arch Neurol VL - 60 IS - 2 N2 - BACKGROUND: The generation of oxygen free radicals is involved in the pathogenesis of Alzheimer disease (AD). OBJECTIVE: To determine whether the intake of antioxidant vitamins decreases the risk of AD. METHODS: We investigated the relationship between AD and the intake of carotenes, vitamin C, and vitamin E in 980 elderly subjects in the Washington Heights-Inwood Columbia Aging Project who were free of dementia at baseline and were followed for a mean time of 4 years. Semiquantitative food frequency questionnaires were administered between baseline and the first follow-up visit. Cox proportional hazards regression models were conducted with quartiles of each vitamin intake as the exposure of interest and incident AD as the outcome, adjusted for age, level of education, sex, APOE epsilon4 status, ethnicity, and smoking. RESULTS: There were 242 incident cases of AD in 4,023 person-years of follow-up (6 per 100 person-years). Intake of carotenes and vitamin C, or vitamin E in supplemental or dietary (nonsupplemental) form or in both forms, was not related to a decreased risk of AD. Trend tests for the association between quartiles of total intake of vitamins C and E also were not significant. CONCLUSION: Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/12580704/Antioxidant_vitamin_intake_and_risk_of_Alzheimer_disease_ DB - PRIME DP - Unbound Medicine ER -