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L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department.

Abstract

Paediatric studies have demonstrated that l-arginine (l-arg), the precursor to nitric oxide, is diminished in vaso-occlusive crisis (VOC). This study aimed to determine whether l-arginine levels are altered in adult VOC in the emergency department. Plasma l-arg and nitric oxide metabolite (NOx) levels were obtained in adult VOC patients presenting to the emergency department. Fifty patients had significantly low plasma l-arg (29.78 micromol/l +/- 11.21, P < 0.05 vs steady-state control = 41.16 micromol/l +/- 5.04) and significantly low plasma NOx (12.33 micromol/l +/- 10.28, P < 0.05 vs steady-state control = 25.2 +/- 2.6 micro mol/l). Neither l-arg nor NOx levels could predict VOC clinical course.

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  • Authors+Show Affiliations

    ,

    Department of Emergency Medicine, Jefferson Medical College, Philadelphia, PA, USA. Bernard.Lopez@mail.tju.edu

    , , , ,

    Source

    British journal of haematology 120:3 2003 Feb pg 532-4

    MeSH

    Acute Disease
    Adult
    Anemia, Sickle Cell
    Arginine
    Biomarkers
    Constriction, Pathologic
    Humans
    Nitric Oxide
    Pain Measurement
    Vascular Diseases

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12580975

    Citation

    Lopez, Bernard L., et al. "L-arginine Levels Are Diminished in Adult Acute Vaso-occlusive Sickle Cell Crisis in the Emergency Department." British Journal of Haematology, vol. 120, no. 3, 2003, pp. 532-4.
    Lopez BL, Kreshak AA, Morris CR, et al. L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. Br J Haematol. 2003;120(3):532-4.
    Lopez, B. L., Kreshak, A. A., Morris, C. R., Davis-Moon, L., Ballas, S. K., & Ma, X. L. (2003). L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. British Journal of Haematology, 120(3), pp. 532-4.
    Lopez BL, et al. L-arginine Levels Are Diminished in Adult Acute Vaso-occlusive Sickle Cell Crisis in the Emergency Department. Br J Haematol. 2003;120(3):532-4. PubMed PMID: 12580975.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. AU - Lopez,Bernard L, AU - Kreshak,Allyson A, AU - Morris,Claudia R, AU - Davis-Moon,Linda, AU - Ballas,Samir K, AU - Ma,Xin-Liang, PY - 2003/2/13/pubmed PY - 2003/4/1/medline PY - 2003/2/13/entrez SP - 532 EP - 4 JF - British journal of haematology JO - Br. J. Haematol. VL - 120 IS - 3 N2 - Paediatric studies have demonstrated that l-arginine (l-arg), the precursor to nitric oxide, is diminished in vaso-occlusive crisis (VOC). This study aimed to determine whether l-arginine levels are altered in adult VOC in the emergency department. Plasma l-arg and nitric oxide metabolite (NOx) levels were obtained in adult VOC patients presenting to the emergency department. Fifty patients had significantly low plasma l-arg (29.78 micromol/l +/- 11.21, P < 0.05 vs steady-state control = 41.16 micromol/l +/- 5.04) and significantly low plasma NOx (12.33 micromol/l +/- 10.28, P < 0.05 vs steady-state control = 25.2 +/- 2.6 micro mol/l). Neither l-arg nor NOx levels could predict VOC clinical course. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/12580975/L_arginine_levels_are_diminished_in_adult_acute_vaso_occlusive_sickle_cell_crisis_in_the_emergency_department_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1048&amp;date=2003&amp;volume=120&amp;issue=3&amp;spage=532 DB - PRIME DP - Unbound Medicine ER -