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Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition.
Mediators Inflamm 2002; 11(6):363-5MI

Abstract

BACKGROUND

Protein-energy malnutrition (PEM) results from food insufficiency as well as from poor social and economic conditions. Development of PEM is due to insufficient nutrition. Children with PEM lose their resistance to infections because of a disordered immune system. It has been reported that the changes occurring in mediators referred to as cytokines in the immune system may be indicators of the disorders associated with PEM.

AIMS

To determine the concentrations of pro-inflammatory cytokines in children with PEM, and to find out whether there was an association with the clinical presentation of PEM.

METHODS

The levels of serum total protein, albumin, tumour necrosis factor-alpha, and interleukin-6 were measured in 25 patients with PEM and in 18 healthy children as a control group. PEM was divided into two groups as kwashiorkor and marasmus. The kwashiorkor group consisted of 15 children and the marasmus group consisted of 10 children.

RESULTS

Levels of serum total protein and albumin of the kwashiorkor group were significantly lower than both the marasmus group and controls (p < 0.05). In view of tumour necrosis factor-alpha levels, there was no difference between groups (p > 0.05). While levels of interleukin-6 in both the marasmus group and the kwashiorkor group were significantly higher compared with controls (p < 0.05), there was no significant difference between the groups of marasmus and kwashiorkor (p > 0.05).

CONCLUSIONS

It was observed that the inflammatory response had increased in children with malnutrition.

Authors+Show Affiliations

Department of Biochemistry, School of Medicine, University of Yüzüncü Yil, Tip Fakültesi, Biyokimya Anabilim Dali, Maras Caddesi, 65300 Van, Turkey. halukdulger@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12581501

Citation

Dülger, Haluk, et al. "Pro-inflammatory Cytokines in Turkish Children With Protein-energy Malnutrition." Mediators of Inflammation, vol. 11, no. 6, 2002, pp. 363-5.
Dülger H, Arik M, Sekeroğlu MR, et al. Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. Mediators Inflamm. 2002;11(6):363-5.
Dülger, H., Arik, M., Sekeroğlu, M. R., Tarakçioğlu, M., Noyan, T., Cesur, Y., & Balahoroğlu, R. (2002). Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. Mediators of Inflammation, 11(6), pp. 363-5.
Dülger H, et al. Pro-inflammatory Cytokines in Turkish Children With Protein-energy Malnutrition. Mediators Inflamm. 2002;11(6):363-5. PubMed PMID: 12581501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. AU - Dülger,Haluk, AU - Arik,Mehmet, AU - Sekeroğlu,M Ramazan, AU - Tarakçioğlu,Mehmet, AU - Noyan,Tevfik, AU - Cesur,Yaşar, AU - Balahoroğlu,Ragip, PY - 2003/2/13/pubmed PY - 2003/6/14/medline PY - 2003/2/13/entrez SP - 363 EP - 5 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 11 IS - 6 N2 - BACKGROUND: Protein-energy malnutrition (PEM) results from food insufficiency as well as from poor social and economic conditions. Development of PEM is due to insufficient nutrition. Children with PEM lose their resistance to infections because of a disordered immune system. It has been reported that the changes occurring in mediators referred to as cytokines in the immune system may be indicators of the disorders associated with PEM. AIMS: To determine the concentrations of pro-inflammatory cytokines in children with PEM, and to find out whether there was an association with the clinical presentation of PEM. METHODS: The levels of serum total protein, albumin, tumour necrosis factor-alpha, and interleukin-6 were measured in 25 patients with PEM and in 18 healthy children as a control group. PEM was divided into two groups as kwashiorkor and marasmus. The kwashiorkor group consisted of 15 children and the marasmus group consisted of 10 children. RESULTS: Levels of serum total protein and albumin of the kwashiorkor group were significantly lower than both the marasmus group and controls (p < 0.05). In view of tumour necrosis factor-alpha levels, there was no difference between groups (p > 0.05). While levels of interleukin-6 in both the marasmus group and the kwashiorkor group were significantly higher compared with controls (p < 0.05), there was no significant difference between the groups of marasmus and kwashiorkor (p > 0.05). CONCLUSIONS: It was observed that the inflammatory response had increased in children with malnutrition. SN - 0962-9351 UR - https://www.unboundmedicine.com/medline/citation/12581501/Pro_inflammatory_cytokines_in_Turkish_children_with_protein_energy_malnutrition_ L2 - https://dx.doi.org/10.1080/0962935021000051566 DB - PRIME DP - Unbound Medicine ER -