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[Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes].
Yao Xue Xue Bao. 2001 Jul; 36(7):489-92.YX

Abstract

AIM

To study the effects of bepridil on the rapidly activating component (IKr), the slowly activating component (IKs) of the delayed rectifier potassium current and the inward rectifier potassium current (IK1) in hypertrophied guinea pig ventricular myocytes.

METHODS

The whole cell patch clamp techniques were used.

RESULTS

In hypertrophied guinea pig ventricular myocytes, bepridil 30 mumol.L-1 markedly inhibited IKr and IKs (by 20.9% and 27.2% at 0 mV and mV, respectively). The effect of bepridil on IKs was larger than on IKr. Bepridil 30 mumol.L-1 also significantly inhibited the inward component of IK1 (by 15.1% at +100 mV), but the reverse potential of IK1 was unaffected. Bepridil (1-100 mumol.L-1) was shown to inhibit IKr and IKs in a concentration-dependent manner. Their IC50 were 46.7 mumol.L-1 and 23.8 mumol.L-1, respectively.

CONCLUSION

Bepridil inhibit IKr, IKs and IK1 in hypertrophied guinea pig ventricular myocytes, which may be important in understanding the antiarrhythmic effects of this drug.

Authors+Show Affiliations

National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12585077

Citation

Zhang, G Q., et al. "[Bepridil Inhibition On the Delayed Rectifier K+ Currents in Thyroxine Induced Hypertrophied Guinea Pig Ventricular Myocytes]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 36, no. 7, 2001, pp. 489-92.
Zhang GQ, Hao XM, Ma YP, et al. [Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes]. Yao Xue Xue Bao. 2001;36(7):489-92.
Zhang, G. Q., Hao, X. M., Ma, Y. P., Zhou, P. A., Wu, C. H., & Dai, D. Z. (2001). [Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 36(7), 489-92.
Zhang GQ, et al. [Bepridil Inhibition On the Delayed Rectifier K+ Currents in Thyroxine Induced Hypertrophied Guinea Pig Ventricular Myocytes]. Yao Xue Xue Bao. 2001;36(7):489-92. PubMed PMID: 12585077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes]. AU - Zhang,G Q, AU - Hao,X M, AU - Ma,Y P, AU - Zhou,P A, AU - Wu,C H, AU - Dai,D Z, PY - 2003/2/15/pubmed PY - 2004/2/28/medline PY - 2003/2/15/entrez SP - 489 EP - 92 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 36 IS - 7 N2 - AIM: To study the effects of bepridil on the rapidly activating component (IKr), the slowly activating component (IKs) of the delayed rectifier potassium current and the inward rectifier potassium current (IK1) in hypertrophied guinea pig ventricular myocytes. METHODS: The whole cell patch clamp techniques were used. RESULTS: In hypertrophied guinea pig ventricular myocytes, bepridil 30 mumol.L-1 markedly inhibited IKr and IKs (by 20.9% and 27.2% at 0 mV and mV, respectively). The effect of bepridil on IKs was larger than on IKr. Bepridil 30 mumol.L-1 also significantly inhibited the inward component of IK1 (by 15.1% at +100 mV), but the reverse potential of IK1 was unaffected. Bepridil (1-100 mumol.L-1) was shown to inhibit IKr and IKs in a concentration-dependent manner. Their IC50 were 46.7 mumol.L-1 and 23.8 mumol.L-1, respectively. CONCLUSION: Bepridil inhibit IKr, IKs and IK1 in hypertrophied guinea pig ventricular myocytes, which may be important in understanding the antiarrhythmic effects of this drug. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/12585077/[Bepridil_inhibition_on_the_delayed_rectifier_K+_currents_in_thyroxine_induced_hypertrophied_guinea_pig_ventricular_myocytes]_ DB - PRIME DP - Unbound Medicine ER -