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[Neuropathology of the cerebral vessels of centenarians].
J Mal Vasc. 2002 Jul; 27 Spec No:S13-8.JM

Abstract

Neuropathological study of brain and brain vessels was performed in two series of 12 and 20 centenarians, focusing on the prevalence of small vessel lesions, infarction, Alzheimer's changes and mental status. These are discussed as a function of vascular risk factors. In the first series (12 cases), there was no correlation between the severity of small vessel lesions: hyalinosis (12/12), mineralisation (10/12), amyloid angiopathy (9/12), vascular risk factors (high blood pressure or diabetes), Alzheimer's lesions. However, there was a tendency for an association between amyloid angiopathy and high density of neurofibrillary tangles. In the second series (20 cases), small infarcts and lacunes were found in 9/20 cases, neurofibrillary tangles and diffuse deposits of A beta peptide were constant, senile plaques were very frequent (19/20). Five patients were demented (one vascular dementia, one Alzheimer dementia, and 3 mixed dementias). These data indicate that: 1) Lesions of the walls of small cerebral vessels do not seem linked to the vascular risk factors observed at the end of the life of centenarians. 2) Cerebral infarcts and lacunes are frequent in these patients, and are responsible, at least in part, for a high proportion of the cognitive dysfunctions. The study of larger series is needed for a better understanding of relationships between vascular and degenerative lesions in the oldest old.

Authors+Show Affiliations

Laboratoire de Neuropathologie R. Escourolle, INSERM U 106 et 360, Association Claude Bernard, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75651 Paris. jean-jacques.hauw@psl.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

12587216

Citation

Hauw, J J., et al. "[Neuropathology of the Cerebral Vessels of Centenarians]." Journal Des Maladies Vasculaires, vol. 27 Spec No, 2002, pp. S13-8.
Hauw JJ, Zekry D, Seilhean D, et al. [Neuropathology of the cerebral vessels of centenarians]. J Mal Vasc. 2002;27 Spec No:S13-8.
Hauw, J. J., Zekry, D., Seilhean, D., Forette, B., Gallinari, C., Laurent, M., Moulias, R., Piette, F., Sachet, A., & Duyckaerts, C. (2002). [Neuropathology of the cerebral vessels of centenarians]. Journal Des Maladies Vasculaires, 27 Spec No, S13-8.
Hauw JJ, et al. [Neuropathology of the Cerebral Vessels of Centenarians]. J Mal Vasc. 2002;27 Spec No:S13-8. PubMed PMID: 12587216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neuropathology of the cerebral vessels of centenarians]. AU - Hauw,J J, AU - Zekry,D, AU - Seilhean,D, AU - Forette,B, AU - Gallinari,C, AU - Laurent,M, AU - Moulias,R, AU - Piette,F, AU - Sachet,A, AU - Duyckaerts,C, PY - 2003/2/18/pubmed PY - 2003/3/20/medline PY - 2003/2/18/entrez SP - S13 EP - 8 JF - Journal des maladies vasculaires JO - J Mal Vasc VL - 27 Spec No N2 - Neuropathological study of brain and brain vessels was performed in two series of 12 and 20 centenarians, focusing on the prevalence of small vessel lesions, infarction, Alzheimer's changes and mental status. These are discussed as a function of vascular risk factors. In the first series (12 cases), there was no correlation between the severity of small vessel lesions: hyalinosis (12/12), mineralisation (10/12), amyloid angiopathy (9/12), vascular risk factors (high blood pressure or diabetes), Alzheimer's lesions. However, there was a tendency for an association between amyloid angiopathy and high density of neurofibrillary tangles. In the second series (20 cases), small infarcts and lacunes were found in 9/20 cases, neurofibrillary tangles and diffuse deposits of A beta peptide were constant, senile plaques were very frequent (19/20). Five patients were demented (one vascular dementia, one Alzheimer dementia, and 3 mixed dementias). These data indicate that: 1) Lesions of the walls of small cerebral vessels do not seem linked to the vascular risk factors observed at the end of the life of centenarians. 2) Cerebral infarcts and lacunes are frequent in these patients, and are responsible, at least in part, for a high proportion of the cognitive dysfunctions. The study of larger series is needed for a better understanding of relationships between vascular and degenerative lesions in the oldest old. SN - 0398-0499 UR - https://www.unboundmedicine.com/medline/citation/12587216/[Neuropathology_of_the_cerebral_vessels_of_centenarians]_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -