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Substance use and cognition in early psychosis.
J Psychiatry Neurosci. 2003 Jan; 28(1):48-54.JP

Abstract

OBJECTIVE

To determine the relation between substance use and cognition in individuals experiencing their first episode of psychosis.

DESIGN

Prospective cross-sectional and longitudinal study.

SETTING

An Early Psychosis Treatment and Prevention Program, an outpatient clinic in a psychiatry department at a university-affiliated hospital.

PARTICIPANTS

Individuals with a psychotic illness who were admitted to an Early Psychosis Program; 266 patients were assessed at initial presentation, 159 at 1 year and 90 at 2 years. Most were outpatients.

MEASURES

The effects of substance use (alcohol, cannabis, hallucinogens, cocaine, stimulants) on cognition were assessed. Substance use was determined by DSM-IV criteria, and the Case Manager Rating Scale was used to determine the level of substance use. A comprehensive cognitive battery of tests was used, and the Positive and Negative Syndrome Scale for schizophrenia was administered to all subjects to determine levels of positive and negative symptoms.

RESULTS

Overall, both cross-sectionally and longitudinally, there were no significant associations between cognitive functioning and the use of various substances. Substance use was associated with higher positive symptoms.

CONCLUSIONS

Individuals with psychotic disorders who show mild-to-moderate abuse of substances, in particular alcohol and cannabis, do not exhibit more cognitive impairment than those who do not do use the substances. However, substance use may have other detrimental effects on the process of the psychotic illness.

Authors+Show Affiliations

Department of Psychology, University of Calgary, Calgary, Alta.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12587850

Citation

Pencer, Alissa, and Jean Addington. "Substance Use and Cognition in Early Psychosis." Journal of Psychiatry & Neuroscience : JPN, vol. 28, no. 1, 2003, pp. 48-54.
Pencer A, Addington J. Substance use and cognition in early psychosis. J Psychiatry Neurosci. 2003;28(1):48-54.
Pencer, A., & Addington, J. (2003). Substance use and cognition in early psychosis. Journal of Psychiatry & Neuroscience : JPN, 28(1), 48-54.
Pencer A, Addington J. Substance Use and Cognition in Early Psychosis. J Psychiatry Neurosci. 2003;28(1):48-54. PubMed PMID: 12587850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Substance use and cognition in early psychosis. AU - Pencer,Alissa, AU - Addington,Jean, PY - 2003/2/18/pubmed PY - 2003/4/18/medline PY - 2003/2/18/entrez SP - 48 EP - 54 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 28 IS - 1 N2 - OBJECTIVE: To determine the relation between substance use and cognition in individuals experiencing their first episode of psychosis. DESIGN: Prospective cross-sectional and longitudinal study. SETTING: An Early Psychosis Treatment and Prevention Program, an outpatient clinic in a psychiatry department at a university-affiliated hospital. PARTICIPANTS: Individuals with a psychotic illness who were admitted to an Early Psychosis Program; 266 patients were assessed at initial presentation, 159 at 1 year and 90 at 2 years. Most were outpatients. MEASURES: The effects of substance use (alcohol, cannabis, hallucinogens, cocaine, stimulants) on cognition were assessed. Substance use was determined by DSM-IV criteria, and the Case Manager Rating Scale was used to determine the level of substance use. A comprehensive cognitive battery of tests was used, and the Positive and Negative Syndrome Scale for schizophrenia was administered to all subjects to determine levels of positive and negative symptoms. RESULTS: Overall, both cross-sectionally and longitudinally, there were no significant associations between cognitive functioning and the use of various substances. Substance use was associated with higher positive symptoms. CONCLUSIONS: Individuals with psychotic disorders who show mild-to-moderate abuse of substances, in particular alcohol and cannabis, do not exhibit more cognitive impairment than those who do not do use the substances. However, substance use may have other detrimental effects on the process of the psychotic illness. SN - 1180-4882 UR - https://www.unboundmedicine.com/medline/citation/12587850/Substance_use_and_cognition_in_early_psychosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12587850.ui DB - PRIME DP - Unbound Medicine ER -