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Dietary vitamin C intake is inversely related to cough and wheeze in young smokers.
Respir Med 2003; 97(2):134-42RM

Abstract

We aimed to investigate whether dietary vitamin C intake, an important antioxidant, is inversely related to self-reported respiratory symptoms in young adults of a community. A random sample of 4300 subjects, aged 20-44 years, living in Bergen, Norway, received a postal questionnaire on respiratory symptoms; 80% responded. Vitamin C intake (mg per week) was estimated from a food-frequency questionnaire asking how often the subject, during the last year, had consumed units of orange juice, oranges, potatoes, carrots and tomatoes. Significant differences in the intake of vitamin C were observed across smoking categories with current smokers having the lowest intake, while there was no variation by gender, age or occupational dust exposure. Dietary vitamin C intake was in univariate analyses inversely related to "morning cough", "chronic cough", "wheeze" and "wheeze ever". After adjusting for gender, age, body mass index, "occupational exposure" pack-years as well as having and stratified on smoking habits in multiple logistic regression analyses, the relationship between dietary vitamin C intake and "cough" and "wheeze" tended to be associated to smoking. The odds ratio (OR) for "morning cough" was 0.68 (95% CI: 0.35-0.95), "chronic cough" OR 0.69 (95% CI: 0.47-1.04) and "wheeze ever" OR 0.75 (95% CI: 0.56-1.01) in current-smokers with dietary vitamin C intake in the upper (> or =395 mg/ week) vs. the lower (<209 mg/week) tertile. The OR for "wheeze" was 0.56 (95% CI: 0.35-0.88) in ex-smokers. The magnitude ofthese effects remained after excluding subjects with supplementary vitamin C intake (n=199) from the statistical analyses. Among young Norwegian adults, having a low prevalence of asthma and high prevalences of smoking-related respiratory symptoms, dietary vitamin C intake may act as an antioxidant and thereby reduce cough and wheeze in smokers having high oxidant stress.

Authors+Show Affiliations

Department of Thoracic Medicine, University of Bergen, Norway. ernst.omenaas@haukeland.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12587963

Citation

Omenaas, E, et al. "Dietary Vitamin C Intake Is Inversely Related to Cough and Wheeze in Young Smokers." Respiratory Medicine, vol. 97, no. 2, 2003, pp. 134-42.
Omenaas E, Fluge O, Buist AS, et al. Dietary vitamin C intake is inversely related to cough and wheeze in young smokers. Respir Med. 2003;97(2):134-42.
Omenaas, E., Fluge, O., Buist, A. S., Vollmer, W. M., & Gulsvik, A. (2003). Dietary vitamin C intake is inversely related to cough and wheeze in young smokers. Respiratory Medicine, 97(2), pp. 134-42.
Omenaas E, et al. Dietary Vitamin C Intake Is Inversely Related to Cough and Wheeze in Young Smokers. Respir Med. 2003;97(2):134-42. PubMed PMID: 12587963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary vitamin C intake is inversely related to cough and wheeze in young smokers. AU - Omenaas,E, AU - Fluge,O, AU - Buist,A S, AU - Vollmer,W M, AU - Gulsvik,A, PY - 2003/2/18/pubmed PY - 2003/5/14/medline PY - 2003/2/18/entrez SP - 134 EP - 42 JF - Respiratory medicine JO - Respir Med VL - 97 IS - 2 N2 - We aimed to investigate whether dietary vitamin C intake, an important antioxidant, is inversely related to self-reported respiratory symptoms in young adults of a community. A random sample of 4300 subjects, aged 20-44 years, living in Bergen, Norway, received a postal questionnaire on respiratory symptoms; 80% responded. Vitamin C intake (mg per week) was estimated from a food-frequency questionnaire asking how often the subject, during the last year, had consumed units of orange juice, oranges, potatoes, carrots and tomatoes. Significant differences in the intake of vitamin C were observed across smoking categories with current smokers having the lowest intake, while there was no variation by gender, age or occupational dust exposure. Dietary vitamin C intake was in univariate analyses inversely related to "morning cough", "chronic cough", "wheeze" and "wheeze ever". After adjusting for gender, age, body mass index, "occupational exposure" pack-years as well as having and stratified on smoking habits in multiple logistic regression analyses, the relationship between dietary vitamin C intake and "cough" and "wheeze" tended to be associated to smoking. The odds ratio (OR) for "morning cough" was 0.68 (95% CI: 0.35-0.95), "chronic cough" OR 0.69 (95% CI: 0.47-1.04) and "wheeze ever" OR 0.75 (95% CI: 0.56-1.01) in current-smokers with dietary vitamin C intake in the upper (> or =395 mg/ week) vs. the lower (<209 mg/week) tertile. The OR for "wheeze" was 0.56 (95% CI: 0.35-0.88) in ex-smokers. The magnitude ofthese effects remained after excluding subjects with supplementary vitamin C intake (n=199) from the statistical analyses. Among young Norwegian adults, having a low prevalence of asthma and high prevalences of smoking-related respiratory symptoms, dietary vitamin C intake may act as an antioxidant and thereby reduce cough and wheeze in smokers having high oxidant stress. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/12587963/Dietary_vitamin_C_intake_is_inversely_related_to_cough_and_wheeze_in_young_smokers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(03)91439-9 DB - PRIME DP - Unbound Medicine ER -