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Postmenopausal breast cancer is associated with high intakes of omega6 fatty acids (Sweden).

Abstract

OBJECTIVE

To estimate the postmenopausal breast cancer risk associated with total fat intake, different types and relative proportions of dietary fat using a nested, matched case-control study within the Malmö Diet and Cancer (MDC) cohort, Sweden.

METHODS

Among women 50 years or older at baseline (n = 12,803), incident breast cancer cases (n = 237) were matched to controls (n = 673) on age and screening date. Data were obtained by a "novel" diet history method, a structured questionnaire, and anthropometric measurements. Conditional logistic regression examined breast cancer risks associated with quintiles of fat intake residuals adjusted for energy and potential confounders.

RESULTS

Saturated fat and the omega3-omega6 fatty acid ratio were not related to increased risks, but positive trends were seen for total (p = 0.031), monounsaturated (p = 0.002), and polyunsaturated fat (p = 0.0009), especially omega6 fatty acids and the polyunsaturated-saturated fat ratio (p = 0.004). With mutual adjustment for different types of fat, an elevated risk remained significant in the highest omega6 fatty acid quintile (RR= 2.08, 95% CI 1.08-4.01).

CONCLUSIONS

Postmenopausal breast cancer was positively associated with total, monounsaturated, and polyunsaturated fat. However, with mutual adjustment for other types of fat, specifically high intakes of omega6 fatty acids were associated with an increased risk.

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  • Authors+Show Affiliations

    ,

    Malmö Diet and Cancer Study: Department of Medicine, Surgery and Orthopedics, Lund University, Sweden. elisabet.wirfalt@smi.mas.lu.se

    , , , ,

    Source

    Cancer causes & control : CCC 13:10 2002 Dec pg 883-93

    MeSH

    Anthropometry
    Breast Neoplasms
    Case-Control Studies
    Chi-Square Distribution
    Dietary Fats
    Fatty Acids, Omega-6
    Fatty Acids, Unsaturated
    Female
    Humans
    Incidence
    Middle Aged
    Postmenopause
    Risk Factors
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12588084

    Citation

    Wirfält, Elisabet, et al. "Postmenopausal Breast Cancer Is Associated With High Intakes of Omega6 Fatty Acids (Sweden)." Cancer Causes & Control : CCC, vol. 13, no. 10, 2002, pp. 883-93.
    Wirfält E, Mattisson I, Gullberg B, et al. Postmenopausal breast cancer is associated with high intakes of omega6 fatty acids (Sweden). Cancer Causes Control. 2002;13(10):883-93.
    Wirfält, E., Mattisson, I., Gullberg, B., Johansson, U., Olsson, H., & Berglund, G. (2002). Postmenopausal breast cancer is associated with high intakes of omega6 fatty acids (Sweden). Cancer Causes & Control : CCC, 13(10), pp. 883-93.
    Wirfält E, et al. Postmenopausal Breast Cancer Is Associated With High Intakes of Omega6 Fatty Acids (Sweden). Cancer Causes Control. 2002;13(10):883-93. PubMed PMID: 12588084.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Postmenopausal breast cancer is associated with high intakes of omega6 fatty acids (Sweden). AU - Wirfält,Elisabet, AU - Mattisson,Irene, AU - Gullberg,Bo, AU - Johansson,Ulla, AU - Olsson,Håkan, AU - Berglund,Göran, PY - 2003/2/18/pubmed PY - 2003/5/21/medline PY - 2003/2/18/entrez SP - 883 EP - 93 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 13 IS - 10 N2 - OBJECTIVE: To estimate the postmenopausal breast cancer risk associated with total fat intake, different types and relative proportions of dietary fat using a nested, matched case-control study within the Malmö Diet and Cancer (MDC) cohort, Sweden. METHODS: Among women 50 years or older at baseline (n = 12,803), incident breast cancer cases (n = 237) were matched to controls (n = 673) on age and screening date. Data were obtained by a "novel" diet history method, a structured questionnaire, and anthropometric measurements. Conditional logistic regression examined breast cancer risks associated with quintiles of fat intake residuals adjusted for energy and potential confounders. RESULTS: Saturated fat and the omega3-omega6 fatty acid ratio were not related to increased risks, but positive trends were seen for total (p = 0.031), monounsaturated (p = 0.002), and polyunsaturated fat (p = 0.0009), especially omega6 fatty acids and the polyunsaturated-saturated fat ratio (p = 0.004). With mutual adjustment for different types of fat, an elevated risk remained significant in the highest omega6 fatty acid quintile (RR= 2.08, 95% CI 1.08-4.01). CONCLUSIONS: Postmenopausal breast cancer was positively associated with total, monounsaturated, and polyunsaturated fat. However, with mutual adjustment for other types of fat, specifically high intakes of omega6 fatty acids were associated with an increased risk. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/12588084/Postmenopausal_breast_cancer_is_associated_with_high_intakes_of_omega6_fatty_acids__Sweden__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12588084.ui DB - PRIME DP - Unbound Medicine ER -