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Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study.
Cancer Causes Control. 2002 Dec; 13(10):957-64.CC

Abstract

OBJECTIVE

To provide information on the effects of alcohol and tobacco on laryngeal cancer and its subsites.

METHODS

This was a case-control study conducted between 1992 and 2000 in northern Italy and Switzerland. A total of 527 cases of incident squamous-cell carcinoma of the larynx and 1297 hospital controls frequency-matched with cases on age, sex, and area of residence were included. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression.

RESULTS

In comparison with never smokers, ORs were 19.8 for current smokers and 7.0 for ex-smokers. The risk increased in relation to the number of cigarettes (OR = 42.9 for > or = 25 cigarettes/day) and for duration of smoking (OR = 37.2 for > or = 40 years). For alcohol, the risk increased in relation to number of drinks (OR = 5.9 for > or = 56 drinks per week). Combined alcohol and tobacco consumption showed a multiplicative (OR = 177) rather than an additive risk. For current smokers and current drinkers the risk was higher for supraglottis (ORs 54.9 and 2.6, respectively) than for glottis (ORs 7.4 and 1.8) and others subsites (ORs 10.9 and 1.9).

CONCLUSIONS

Our study shows that both cigarette smoking and alcohol drinking are independent risk factors for laryngeal cancer. Heavy consumption of alcohol and cigarettes determined a multiplicative risk increase, possibly suggesting biological synergy.

Authors+Show Affiliations

Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy. talaminir@cro.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12588092

Citation

Talamini, R, et al. "Combined Effect of Tobacco and Alcohol On Laryngeal Cancer Risk: a Case-control Study." Cancer Causes & Control : CCC, vol. 13, no. 10, 2002, pp. 957-64.
Talamini R, Bosetti C, La Vecchia C, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002;13(10):957-64.
Talamini, R., Bosetti, C., La Vecchia, C., Dal Maso, L., Levi, F., Bidoli, E., Negri, E., Pasche, C., Vaccarella, S., Barzan, L., & Franceschi, S. (2002). Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes & Control : CCC, 13(10), 957-64.
Talamini R, et al. Combined Effect of Tobacco and Alcohol On Laryngeal Cancer Risk: a Case-control Study. Cancer Causes Control. 2002;13(10):957-64. PubMed PMID: 12588092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. AU - Talamini,R, AU - Bosetti,C, AU - La Vecchia,C, AU - Dal Maso,L, AU - Levi,F, AU - Bidoli,E, AU - Negri,E, AU - Pasche,C, AU - Vaccarella,S, AU - Barzan,L, AU - Franceschi,S, PY - 2003/2/18/pubmed PY - 2003/5/21/medline PY - 2003/2/18/entrez SP - 957 EP - 64 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 13 IS - 10 N2 - OBJECTIVE: To provide information on the effects of alcohol and tobacco on laryngeal cancer and its subsites. METHODS: This was a case-control study conducted between 1992 and 2000 in northern Italy and Switzerland. A total of 527 cases of incident squamous-cell carcinoma of the larynx and 1297 hospital controls frequency-matched with cases on age, sex, and area of residence were included. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression. RESULTS: In comparison with never smokers, ORs were 19.8 for current smokers and 7.0 for ex-smokers. The risk increased in relation to the number of cigarettes (OR = 42.9 for > or = 25 cigarettes/day) and for duration of smoking (OR = 37.2 for > or = 40 years). For alcohol, the risk increased in relation to number of drinks (OR = 5.9 for > or = 56 drinks per week). Combined alcohol and tobacco consumption showed a multiplicative (OR = 177) rather than an additive risk. For current smokers and current drinkers the risk was higher for supraglottis (ORs 54.9 and 2.6, respectively) than for glottis (ORs 7.4 and 1.8) and others subsites (ORs 10.9 and 1.9). CONCLUSIONS: Our study shows that both cigarette smoking and alcohol drinking are independent risk factors for laryngeal cancer. Heavy consumption of alcohol and cigarettes determined a multiplicative risk increase, possibly suggesting biological synergy. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/12588092/Combined_effect_of_tobacco_and_alcohol_on_laryngeal_cancer_risk:_a_case_control_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12588092.ui DB - PRIME DP - Unbound Medicine ER -