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RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta-independent activation of p21Waf1/Cip1.
Nutr Cancer. 2002; 43(2):227-36.NC

Abstract

RRR-alpha-tocopheryl succinate (vitamin E succinate, VES), a derivative of vitamin E, is a potent antitumor agent. Cellular events involved in VES-induced DNA synthesis arrest of human MDA-MB-435 breast cancer cells were studied. VES induces a dose- and time-dependent inhibition of DNA synthesis and a G0/G1 cell cycle arrest. VES induces expression of p21Waf1/Cip1 mRNA and protein, and antisense oligomers to p21 block VES-induced growth arrest. Evidence suggesting that VES modulates p21 expression in a transforming growth factor-beta (TGF-beta)-independent fashion includes failure of TGF-beta-neutralizing antibodies to block VES-induced DNA synthesis arrest or VES activation of a p21 promoter-regulated reporter gene; VES is not capable of inducing the translocation of green fluorescent protein-Smad2 into the nucleus and is not capable of stimulating a TGF-beta-dependent reporter gene, and VES induces growth inhibition and upregulates p21 mRNA levels in TGF-beta receptor-defective cells.

Authors+Show Affiliations

School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12588702

Citation

Yu, Weiping, et al. "RRR-alpha-tocopheryl Succinate Induction of DNA Synthesis Arrest of Human MDA-MB-435 Cells Involves TGF-beta-independent Activation of P21Waf1/Cip1." Nutrition and Cancer, vol. 43, no. 2, 2002, pp. 227-36.
Yu W, Sanders BG, Kline K. RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta-independent activation of p21Waf1/Cip1. Nutr Cancer. 2002;43(2):227-36.
Yu, W., Sanders, B. G., & Kline, K. (2002). RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta-independent activation of p21Waf1/Cip1. Nutrition and Cancer, 43(2), 227-36.
Yu W, Sanders BG, Kline K. RRR-alpha-tocopheryl Succinate Induction of DNA Synthesis Arrest of Human MDA-MB-435 Cells Involves TGF-beta-independent Activation of P21Waf1/Cip1. Nutr Cancer. 2002;43(2):227-36. PubMed PMID: 12588702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta-independent activation of p21Waf1/Cip1. AU - Yu,Weiping, AU - Sanders,Bob G, AU - Kline,Kimberly, PY - 2003/2/18/pubmed PY - 2003/5/30/medline PY - 2003/2/18/entrez SP - 227 EP - 36 JF - Nutrition and cancer JO - Nutr Cancer VL - 43 IS - 2 N2 - RRR-alpha-tocopheryl succinate (vitamin E succinate, VES), a derivative of vitamin E, is a potent antitumor agent. Cellular events involved in VES-induced DNA synthesis arrest of human MDA-MB-435 breast cancer cells were studied. VES induces a dose- and time-dependent inhibition of DNA synthesis and a G0/G1 cell cycle arrest. VES induces expression of p21Waf1/Cip1 mRNA and protein, and antisense oligomers to p21 block VES-induced growth arrest. Evidence suggesting that VES modulates p21 expression in a transforming growth factor-beta (TGF-beta)-independent fashion includes failure of TGF-beta-neutralizing antibodies to block VES-induced DNA synthesis arrest or VES activation of a p21 promoter-regulated reporter gene; VES is not capable of inducing the translocation of green fluorescent protein-Smad2 into the nucleus and is not capable of stimulating a TGF-beta-dependent reporter gene, and VES induces growth inhibition and upregulates p21 mRNA levels in TGF-beta receptor-defective cells. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/12588702/RRR_alpha_tocopheryl_succinate_induction_of_DNA_synthesis_arrest_of_human_MDA_MB_435_cells_involves_TGF_beta_independent_activation_of_p21Waf1/Cip1_ DB - PRIME DP - Unbound Medicine ER -