Tags

Type your tag names separated by a space and hit enter

Effect of probiotic Lactobacillus strains in children with atopic dermatitis.
J Allergy Clin Immunol. 2003 Feb; 111(2):389-95.JA

Abstract

BACKGROUND

Recent studies suggest that oral bacteriotherapy with probiotics might be useful in the management of atopic dermatitis (AD).

OBJECTIVE

The purpose of this investigation was to evaluate the clinical and anti-inflammatory effect of probiotic supplementation in children with AD.

METHODS

In a double-blind, placebo-controlled, crossover study, 2 probiotic Lactobacillus strains (lyophilized Lactobacillus rhamnosus 19070-2 and Lactobacillus reuteri DSM 122460) were given in combination for 6 weeks to 1- to 13-year-old children with AD. The patients' evaluations were registered after each intervention (ie, better, unchanged, or worse). The clinical severity of the eczema was evaluated by using the scoring atopic dermatitis (SCORAD) score. As inflammatory markers, eosinophil cationic protein in serum and cytokine production by PBMCs were measured.

RESULTS

After active treatment, 56% of the patients experienced improvement of the eczema, whereas only 15% believed their symptoms had improved after placebo (P =.001). The total SCORAD index, however, did not change significantly. The extent of the eczema decreased during active treatment from a mean of 18.2% to 13.7% (P =.02). The treatment response was more pronounced in allergic patients (at least one positive skin prick test response and elevated IgE levels), and in this group the SCORAD score decreased (P =.02 compared with nonallergic patients). During active treatment, serum eosinophil cationic protein levels decreased (P =.03). No significant changes in the production of the cytokines IL-2, IL-4, IL-10, or IFN-gamma were found.

CONCLUSIONS

A combination of L rhamnosus 19070-2 and L reuteri DSM 122460 was beneficial in the management of AD. The effect was more pronounced in patients with a positive skin prick test response and increased IgE levels.

Authors+Show Affiliations

Research Department of Human Nutrition and the LMC Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12589361

Citation

Rosenfeldt, Vibeke, et al. "Effect of Probiotic Lactobacillus Strains in Children With Atopic Dermatitis." The Journal of Allergy and Clinical Immunology, vol. 111, no. 2, 2003, pp. 389-95.
Rosenfeldt V, Benfeldt E, Nielsen SD, et al. Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol. 2003;111(2):389-95.
Rosenfeldt, V., Benfeldt, E., Nielsen, S. D., Michaelsen, K. F., Jeppesen, D. L., Valerius, N. H., & Paerregaard, A. (2003). Effect of probiotic Lactobacillus strains in children with atopic dermatitis. The Journal of Allergy and Clinical Immunology, 111(2), 389-95.
Rosenfeldt V, et al. Effect of Probiotic Lactobacillus Strains in Children With Atopic Dermatitis. J Allergy Clin Immunol. 2003;111(2):389-95. PubMed PMID: 12589361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of probiotic Lactobacillus strains in children with atopic dermatitis. AU - Rosenfeldt,Vibeke, AU - Benfeldt,Eva, AU - Nielsen,Susanne Dam, AU - Michaelsen,Kim Fleischer, AU - Jeppesen,Dorthe Lisbeth, AU - Valerius,Niels Henrik, AU - Paerregaard,Anders, PY - 2003/2/18/pubmed PY - 2003/3/26/medline PY - 2003/2/18/entrez SP - 389 EP - 95 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 111 IS - 2 N2 - BACKGROUND: Recent studies suggest that oral bacteriotherapy with probiotics might be useful in the management of atopic dermatitis (AD). OBJECTIVE: The purpose of this investigation was to evaluate the clinical and anti-inflammatory effect of probiotic supplementation in children with AD. METHODS: In a double-blind, placebo-controlled, crossover study, 2 probiotic Lactobacillus strains (lyophilized Lactobacillus rhamnosus 19070-2 and Lactobacillus reuteri DSM 122460) were given in combination for 6 weeks to 1- to 13-year-old children with AD. The patients' evaluations were registered after each intervention (ie, better, unchanged, or worse). The clinical severity of the eczema was evaluated by using the scoring atopic dermatitis (SCORAD) score. As inflammatory markers, eosinophil cationic protein in serum and cytokine production by PBMCs were measured. RESULTS: After active treatment, 56% of the patients experienced improvement of the eczema, whereas only 15% believed their symptoms had improved after placebo (P =.001). The total SCORAD index, however, did not change significantly. The extent of the eczema decreased during active treatment from a mean of 18.2% to 13.7% (P =.02). The treatment response was more pronounced in allergic patients (at least one positive skin prick test response and elevated IgE levels), and in this group the SCORAD score decreased (P =.02 compared with nonallergic patients). During active treatment, serum eosinophil cationic protein levels decreased (P =.03). No significant changes in the production of the cytokines IL-2, IL-4, IL-10, or IFN-gamma were found. CONCLUSIONS: A combination of L rhamnosus 19070-2 and L reuteri DSM 122460 was beneficial in the management of AD. The effect was more pronounced in patients with a positive skin prick test response and increased IgE levels. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/12589361/Effect_of_probiotic_Lactobacillus_strains_in_children_with_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674902913734 DB - PRIME DP - Unbound Medicine ER -