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Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1.
Clin Sci (Lond) 2003; 105(1):13-20CS

Abstract

We have investigated the effect of fish oil supplementation on the association between serum non-esterified fatty acid (NEFA) pattern and atherosclerotic activity. We studied correlations between serum non-esterified very long-chain eicosapentaenoic (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) and biochemical markers of endothelial activation before and after 18-months intervention with fish oil supplementation. The fish oil supplementation consisted of 2.4 g of EPA and DHA per day, with corn oil as placebo. Elderly men (n =171) with high risk for coronary heart disease were divided into four intervention groups in a factorial design: fish oil supplementation (n =44), dietary intervention (n =42), fish oil supplementation+dietary intervention (n =47) or placebo (n =38). The composition of fasting NEFA was analysed before and after intervention by GLC. Circulating endothelial markers were analysed by ELISA. A statistically significant positive correlation between the change in serum non-esterified DHA and soluble vascular cell adhesion molecule-1 (sVCAM-1) was found in the pooled group that received fish oil supplementation (n =91; Spearman's correlation coefficient r =0.24, P =0.02). No such correlation was found in the pooled group without fish oil supplementation (n =80). Furthermore, there was a significant negative correlation between the change in serum non-esterified EPA and the relative change in sVCAM-1 in the group that did not receive fish oil supplementation (r =-0.34, P =0.002). No such correlation was found in the group with fish oil supplementation. We conclude that large increase in serum non-esterified EPA and DHA, which can only be attained by supplementation, might increase inflammation in vascular endothelium. A moderate dietary increase in fish oil intake may, however, have an effect on decreasing inflammatory markers.

Authors+Show Affiliations

Institute for Nutrition Research, University of Oslo, P.O. Box 1046 Blindern, N-0316 Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12589702

Citation

Berstad, Paula, et al. "Supplementation With Fish Oil Affects the Association Between Very Long-chain N-3 Polyunsaturated Fatty Acids in Serum Non-esterified Fatty Acids and Soluble Vascular Cell Adhesion Molecule-1." Clinical Science (London, England : 1979), vol. 105, no. 1, 2003, pp. 13-20.
Berstad P, Seljeflot I, Veierød MB, et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci. 2003;105(1):13-20.
Berstad, P., Seljeflot, I., Veierød, M. B., Hjerkinn, E. M., Arnesen, H., & Pedersen, J. I. (2003). Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clinical Science (London, England : 1979), 105(1), pp. 13-20.
Berstad P, et al. Supplementation With Fish Oil Affects the Association Between Very Long-chain N-3 Polyunsaturated Fatty Acids in Serum Non-esterified Fatty Acids and Soluble Vascular Cell Adhesion Molecule-1. Clin Sci. 2003;105(1):13-20. PubMed PMID: 12589702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. AU - Berstad,Paula, AU - Seljeflot,Ingebjørg, AU - Veierød,Marit B, AU - Hjerkinn,Elsa M, AU - Arnesen,Harald, AU - Pedersen,Jan I, PY - 2003/02/17/accepted PY - 2003/02/13/revised PY - 2002/12/05/received PY - 2003/2/19/pubmed PY - 2003/9/23/medline PY - 2003/2/19/entrez SP - 13 EP - 20 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 105 IS - 1 N2 - We have investigated the effect of fish oil supplementation on the association between serum non-esterified fatty acid (NEFA) pattern and atherosclerotic activity. We studied correlations between serum non-esterified very long-chain eicosapentaenoic (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) and biochemical markers of endothelial activation before and after 18-months intervention with fish oil supplementation. The fish oil supplementation consisted of 2.4 g of EPA and DHA per day, with corn oil as placebo. Elderly men (n =171) with high risk for coronary heart disease were divided into four intervention groups in a factorial design: fish oil supplementation (n =44), dietary intervention (n =42), fish oil supplementation+dietary intervention (n =47) or placebo (n =38). The composition of fasting NEFA was analysed before and after intervention by GLC. Circulating endothelial markers were analysed by ELISA. A statistically significant positive correlation between the change in serum non-esterified DHA and soluble vascular cell adhesion molecule-1 (sVCAM-1) was found in the pooled group that received fish oil supplementation (n =91; Spearman's correlation coefficient r =0.24, P =0.02). No such correlation was found in the pooled group without fish oil supplementation (n =80). Furthermore, there was a significant negative correlation between the change in serum non-esterified EPA and the relative change in sVCAM-1 in the group that did not receive fish oil supplementation (r =-0.34, P =0.002). No such correlation was found in the group with fish oil supplementation. We conclude that large increase in serum non-esterified EPA and DHA, which can only be attained by supplementation, might increase inflammation in vascular endothelium. A moderate dietary increase in fish oil intake may, however, have an effect on decreasing inflammatory markers. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/12589702/Supplementation_with_fish_oil_affects_the_association_between_very_long_chain_n_3_polyunsaturated_fatty_acids_in_serum_non_esterified_fatty_acids_and_soluble_vascular_cell_adhesion_molecule_1_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&pmid=12589702 DB - PRIME DP - Unbound Medicine ER -