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Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1.

Abstract

We have investigated the effect of fish oil supplementation on the association between serum non-esterified fatty acid (NEFA) pattern and atherosclerotic activity. We studied correlations between serum non-esterified very long-chain eicosapentaenoic (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) and biochemical markers of endothelial activation before and after 18-months intervention with fish oil supplementation. The fish oil supplementation consisted of 2.4 g of EPA and DHA per day, with corn oil as placebo. Elderly men ( n =171) with high risk for coronary heart disease were divided into four intervention groups in a factorial design: fish oil supplementation ( n =44), dietary intervention ( n =42), fish oil supplementation+dietary intervention ( n =47) or placebo ( n =38). The composition of fasting NEFA was analysed before and after intervention by GLC. Circulating endothelial markers were analysed by ELISA. A statistically significant positive correlation between the change in serum non-esterified DHA and soluble vascular cell adhesion molecule-1 (sVCAM-1) was found in the pooled group that received fish oil supplementation ( n =91; Spearman's correlation coefficient r =0.24, P =0.02). No such correlation was found in the pooled group without fish oil supplementation ( n =80). Furthermore, there was a significant negative correlation between the change in serum non-esterified EPA and the relative change in sVCAM-1 in the group that did not receive fish oil supplementation ( r =-0.34, P =0.002). No such correlation was found in the group with fish oil supplementation. We conclude that large increase in serum non-esterified EPA and DHA, which can only be attained by supplementation, might increase inflammation in vascular endothelium. A moderate dietary increase in fish oil intake may, however, have an effect on decreasing inflammatory markers.

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  • Authors+Show Affiliations

    ,

    Institute for Nutrition Research, University of Oslo, P.O. Box 1046 Blindern, N-0316 Oslo, Norway.

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    Source

    MeSH

    Aged
    Arachidonic Acid
    Biomarkers
    Coronary Disease
    Diet
    Dietary Supplements
    Docosahexaenoic Acids
    Double-Blind Method
    Eicosapentaenoic Acid
    Fatty Acids, Nonesterified
    Fatty Acids, Omega-3
    Fish Oils
    Humans
    Male
    Prospective Studies
    Regression Analysis
    Vascular Cell Adhesion Molecule-1

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12589702

    Citation

    Berstad, Paula, et al. "Supplementation With Fish Oil Affects the Association Between Very Long-chain N-3 Polyunsaturated Fatty Acids in Serum Non-esterified Fatty Acids and Soluble Vascular Cell Adhesion Molecule-1." Clinical Science (London, England : 1979), vol. 105, no. 1, 2003, pp. 13-20.
    Berstad P, Seljeflot I, Veierød MB, et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci. 2003;105(1):13-20.
    Berstad, P., Seljeflot, I., Veierød, M. B., Hjerkinn, E. M., Arnesen, H., & Pedersen, J. I. (2003). Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clinical Science (London, England : 1979), 105(1), pp. 13-20.
    Berstad P, et al. Supplementation With Fish Oil Affects the Association Between Very Long-chain N-3 Polyunsaturated Fatty Acids in Serum Non-esterified Fatty Acids and Soluble Vascular Cell Adhesion Molecule-1. Clin Sci. 2003;105(1):13-20. PubMed PMID: 12589702.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. AU - Berstad,Paula, AU - Seljeflot,Ingebjørg, AU - Veierød,Marit B, AU - Hjerkinn,Elsa M, AU - Arnesen,Harald, AU - Pedersen,Jan I, PY - 2003/02/17/accepted PY - 2003/02/13/revised PY - 2002/12/05/received PY - 2003/2/19/pubmed PY - 2003/9/23/medline PY - 2003/2/19/entrez SP - 13 EP - 20 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 105 IS - 1 N2 - We have investigated the effect of fish oil supplementation on the association between serum non-esterified fatty acid (NEFA) pattern and atherosclerotic activity. We studied correlations between serum non-esterified very long-chain eicosapentaenoic (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) and biochemical markers of endothelial activation before and after 18-months intervention with fish oil supplementation. The fish oil supplementation consisted of 2.4 g of EPA and DHA per day, with corn oil as placebo. Elderly men ( n =171) with high risk for coronary heart disease were divided into four intervention groups in a factorial design: fish oil supplementation ( n =44), dietary intervention ( n =42), fish oil supplementation+dietary intervention ( n =47) or placebo ( n =38). The composition of fasting NEFA was analysed before and after intervention by GLC. Circulating endothelial markers were analysed by ELISA. A statistically significant positive correlation between the change in serum non-esterified DHA and soluble vascular cell adhesion molecule-1 (sVCAM-1) was found in the pooled group that received fish oil supplementation ( n =91; Spearman's correlation coefficient r =0.24, P =0.02). No such correlation was found in the pooled group without fish oil supplementation ( n =80). Furthermore, there was a significant negative correlation between the change in serum non-esterified EPA and the relative change in sVCAM-1 in the group that did not receive fish oil supplementation ( r =-0.34, P =0.002). No such correlation was found in the group with fish oil supplementation. We conclude that large increase in serum non-esterified EPA and DHA, which can only be attained by supplementation, might increase inflammation in vascular endothelium. A moderate dietary increase in fish oil intake may, however, have an effect on decreasing inflammatory markers. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/12589702/Supplementation_with_fish_oil_affects_the_association_between_very_long_chain_n_3_polyunsaturated_fatty_acids_in_serum_non_esterified_fatty_acids_and_soluble_vascular_cell_adhesion_molecule_1_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&pmid=12589702 DB - PRIME DP - Unbound Medicine ER -