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Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial.
Am J Gastroenterol. 2003 Feb; 98(2):348-53.AJ

Abstract

OBJECTIVE

We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress.

METHODS

This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid.

RESULTS

During supplementation, plasma vitamin C and alpha-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable.

CONCLUSIONS

In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins.

Authors+Show Affiliations

Gastroenterology and Nutrition Research, Department of Medicine, Toronto General Hospital, University Health Network, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12591053

Citation

Aghdassi, Elaheh, et al. "Antioxidant Vitamin Supplementation in Crohn's Disease Decreases Oxidative Stress. a Randomized Controlled Trial." The American Journal of Gastroenterology, vol. 98, no. 2, 2003, pp. 348-53.
Aghdassi E, Wendland BE, Steinhart AH, et al. Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial. Am J Gastroenterol. 2003;98(2):348-53.
Aghdassi, E., Wendland, B. E., Steinhart, A. H., Wolman, S. L., Jeejeebhoy, K., & Allard, J. P. (2003). Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial. The American Journal of Gastroenterology, 98(2), 348-53.
Aghdassi E, et al. Antioxidant Vitamin Supplementation in Crohn's Disease Decreases Oxidative Stress. a Randomized Controlled Trial. Am J Gastroenterol. 2003;98(2):348-53. PubMed PMID: 12591053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial. AU - Aghdassi,Elaheh, AU - Wendland,Barbara E, AU - Steinhart,A Hillary, AU - Wolman,Stephen L, AU - Jeejeebhoy,Khursheed, AU - Allard,Johane P, PY - 2003/2/20/pubmed PY - 2003/4/2/medline PY - 2003/2/20/entrez SP - 348 EP - 53 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 98 IS - 2 N2 - OBJECTIVE: We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress. METHODS: This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid. RESULTS: During supplementation, plasma vitamin C and alpha-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable. CONCLUSIONS: In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12591053/Antioxidant_vitamin_supplementation_in_Crohn's_disease_decreases_oxidative_stress__a_randomized_controlled_trial_ L2 - https://doi.org/10.1111/j.1572-0241.2003.07226.x DB - PRIME DP - Unbound Medicine ER -