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Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels.
Int Arch Occup Environ Health. 2003 Feb; 76(1):17-23.IA

Abstract

OBJECTIVE

To examine whether unmetabolized methyl isobutyl ketone in urine is a useful marker of low-level occupational exposure to this ketone solvent, as is the case for methyl ethyl ketone.

METHODS

The study was conducted in the second half of a working week. In total, 27 furniture-making workers (19 men and eight women) and 11 non-exposed controls (six men and five women) volunteered to participate in the study. Time-weighted average (TWA; 8-h) concentration of vapors of several solvents in air, including methyl isobutyl ketone (MIBK-A) and methyl ethyl ketone (MEK-A) was monitored by diffusive sampling. Urine samples collected at the end of the shift were subjected to head-space gas chromatography (GC) analysis for the unmetabolized solvents (i.e., MIBK-U and MEK-U). The relationship between the concentration of the solvent vapor and the corresponding solvent level in urine was examined by simple as well as multiple regression analysis.

RESULTS

The exposures to MIBK and MEK were well below the current occupational exposure limit levels, but the maximum levels of exposure to toluene and ethylbenzene were around the corresponding exposure limit. The correlation of the TWA concentration of the solvent in air with the concentration of the corresponding solvent in the end-of-shift urine sample was significant both for MIBK and for MEK, and the correlation coefficient was larger for MIBK than for MEK. The slope in the exposure-excretion regression line was almost twice as steep for MEK than for MIBK, possibly due to the difference in water solubility. Approximately 0.12% of MIBK absorbed in the lungs will be excreted into urine, whereas the yield for MEK was somewhat higher (0.19%).

CONCLUSION

MIBK in urine is a good marker of exposure to MIBK, as in the case of MEK in urine for MEK exposure.

Authors+Show Affiliations

Osaka Occupational Health Service Center, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12592578

Citation

Kawai, T, et al. "Methyl Isobutyl Ketone and Methyl Ethyl Ketone in Urine as Biological Markers of Occupational Exposure to These Solvents at Low Levels." International Archives of Occupational and Environmental Health, vol. 76, no. 1, 2003, pp. 17-23.
Kawai T, Zhang ZW, Takeuchi A, et al. Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. Int Arch Occup Environ Health. 2003;76(1):17-23.
Kawai, T., Zhang, Z. W., Takeuchi, A., Miyama, Y., Sakamoto, K., Higashikawa, K., & Ikeda, M. (2003). Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. International Archives of Occupational and Environmental Health, 76(1), 17-23.
Kawai T, et al. Methyl Isobutyl Ketone and Methyl Ethyl Ketone in Urine as Biological Markers of Occupational Exposure to These Solvents at Low Levels. Int Arch Occup Environ Health. 2003;76(1):17-23. PubMed PMID: 12592578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. AU - Kawai,T, AU - Zhang,Z-W, AU - Takeuchi,A, AU - Miyama,Y, AU - Sakamoto,K, AU - Higashikawa,K, AU - Ikeda,M, Y1 - 2002/09/18/ PY - 2002/03/03/received PY - 2002/06/28/accepted PY - 2003/2/20/pubmed PY - 2003/6/19/medline PY - 2003/2/20/entrez SP - 17 EP - 23 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 76 IS - 1 N2 - OBJECTIVE: To examine whether unmetabolized methyl isobutyl ketone in urine is a useful marker of low-level occupational exposure to this ketone solvent, as is the case for methyl ethyl ketone. METHODS: The study was conducted in the second half of a working week. In total, 27 furniture-making workers (19 men and eight women) and 11 non-exposed controls (six men and five women) volunteered to participate in the study. Time-weighted average (TWA; 8-h) concentration of vapors of several solvents in air, including methyl isobutyl ketone (MIBK-A) and methyl ethyl ketone (MEK-A) was monitored by diffusive sampling. Urine samples collected at the end of the shift were subjected to head-space gas chromatography (GC) analysis for the unmetabolized solvents (i.e., MIBK-U and MEK-U). The relationship between the concentration of the solvent vapor and the corresponding solvent level in urine was examined by simple as well as multiple regression analysis. RESULTS: The exposures to MIBK and MEK were well below the current occupational exposure limit levels, but the maximum levels of exposure to toluene and ethylbenzene were around the corresponding exposure limit. The correlation of the TWA concentration of the solvent in air with the concentration of the corresponding solvent in the end-of-shift urine sample was significant both for MIBK and for MEK, and the correlation coefficient was larger for MIBK than for MEK. The slope in the exposure-excretion regression line was almost twice as steep for MEK than for MIBK, possibly due to the difference in water solubility. Approximately 0.12% of MIBK absorbed in the lungs will be excreted into urine, whereas the yield for MEK was somewhat higher (0.19%). CONCLUSION: MIBK in urine is a good marker of exposure to MIBK, as in the case of MEK in urine for MEK exposure. SN - 0340-0131 UR - https://www.unboundmedicine.com/medline/citation/12592578/Methyl_isobutyl_ketone_and_methyl_ethyl_ketone_in_urine_as_biological_markers_of_occupational_exposure_to_these_solvents_at_low_levels_ L2 - https://dx.doi.org/10.1007/s00420-002-0374-9 DB - PRIME DP - Unbound Medicine ER -