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Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing.
J Otolaryngol. 2002 Dec; 31(6):376-80.JO

Abstract

OBJECTIVE

To establish the relationship between the macroscopic and histologic diagnosis of nodules, polyps, and Reinke's edema of the true vocal folds and to propose a clearer clinical definition of them in the hope of settling the difference of opinion between otolaryngologists and pathologists.

DESIGN

Retrospective study

SETTING

Otolaryngology Department of "La Sapienza" University of Rome.

METHODS

The pathologic reports of 203 patients subjected to direct laryngoscopy were studied.

MAIN OUTCOME MEASURES

Examination of the histologic specimen of the epithelium and the chorion.

RESULTS

Microscopic examination revealed a high percentage of normal epithelium both for nodules (33.79%) and polyps (40.65%). No dysplasia was observed, whereas dysplasia was present in 10 cases of Reinke's edema (7 laryngeal intraepithelial neoplasia 1 and 3 laryngeal intraepithelial neoplasia II). Five different stages of histologic progression resulted from the examination of the chorion in both nodules and polyps.

CONCLUSIONS

Our suggestion is to consider polyps as "older" lesions and nodules as "younger" lesions. A polyp may be defined as an abnormal unilateral growth of vocal folds, a nodule as a bilateral growth situated between the anterior and medium third of the vocal fold, and Reinke's edema as a bilateral wound that extends to the whole of the true vocal fold.

Authors+Show Affiliations

Department of Otolaryngology, Policlinico Umberto I, "La Sapienza" University, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12593551

Citation

Marcotullio, Dario, et al. "Exudative Laryngeal Diseases of Reinke's Space: a Clinicohistopathological Framing." The Journal of Otolaryngology, vol. 31, no. 6, 2002, pp. 376-80.
Marcotullio D, Magliulo G, Pietrunti S, et al. Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. J Otolaryngol. 2002;31(6):376-80.
Marcotullio, D., Magliulo, G., Pietrunti, S., & Suriano, M. (2002). Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. The Journal of Otolaryngology, 31(6), 376-80.
Marcotullio D, et al. Exudative Laryngeal Diseases of Reinke's Space: a Clinicohistopathological Framing. J Otolaryngol. 2002;31(6):376-80. PubMed PMID: 12593551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. AU - Marcotullio,Dario, AU - Magliulo,Giuseppe, AU - Pietrunti,Stefano, AU - Suriano,Maria, PY - 2003/2/21/pubmed PY - 2003/5/15/medline PY - 2003/2/21/entrez SP - 376 EP - 80 JF - The Journal of otolaryngology JO - J Otolaryngol VL - 31 IS - 6 N2 - OBJECTIVE: To establish the relationship between the macroscopic and histologic diagnosis of nodules, polyps, and Reinke's edema of the true vocal folds and to propose a clearer clinical definition of them in the hope of settling the difference of opinion between otolaryngologists and pathologists. DESIGN: Retrospective study SETTING: Otolaryngology Department of "La Sapienza" University of Rome. METHODS: The pathologic reports of 203 patients subjected to direct laryngoscopy were studied. MAIN OUTCOME MEASURES: Examination of the histologic specimen of the epithelium and the chorion. RESULTS: Microscopic examination revealed a high percentage of normal epithelium both for nodules (33.79%) and polyps (40.65%). No dysplasia was observed, whereas dysplasia was present in 10 cases of Reinke's edema (7 laryngeal intraepithelial neoplasia 1 and 3 laryngeal intraepithelial neoplasia II). Five different stages of histologic progression resulted from the examination of the chorion in both nodules and polyps. CONCLUSIONS: Our suggestion is to consider polyps as "older" lesions and nodules as "younger" lesions. A polyp may be defined as an abnormal unilateral growth of vocal folds, a nodule as a bilateral growth situated between the anterior and medium third of the vocal fold, and Reinke's edema as a bilateral wound that extends to the whole of the true vocal fold. SN - 0381-6605 UR - https://www.unboundmedicine.com/medline/citation/12593551/Exudative_laryngeal_diseases_of_Reinke's_space:_a_clinicohistopathological_framing_ L2 - https://medlineplus.gov/birthmarks.html DB - PRIME DP - Unbound Medicine ER -