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Effect of PVP K-25 on the formation of the naproxen:beta-ciclodextrin complex.
Int J Pharm. 2003 Mar 06; 253(1-2):97-110.IJ

Abstract

The aim of this study was to investigate the effects of the presence of the water-soluble polymer polyvinylpyrrolidone K-25 (MW=24000g/mol) on the complexation of the AINE naproxen, in its sodium salt form, with the beta-cyclodextrin. The data revealed that the polyvinylpyrrolidone K-25 interacts with the drug as well as with the drug:beta-cyclodextrin inclusion complex. The polymer shows more affinity for the inclusion complex, K=(6.67+/-0.292) x 10(-5)M(-1) than for the free drug, (2.08+/-0.208) x 10(-5)M(-1). The presence of different proportions of polymer, in a range 0-1% (w/w) of polyvinylpyrrolidone, does not increase the ability of drug-cyclodextrin complexation but important changes in the driving force of complex formation were detected, depending on the percentage of polyvinylpyrrolidone K-25 present. At low polymer concentrations, the complexation process is driven entropically, while at higher PVP proportions it is enthalpically favored. In the ternary system, polyvinylpyrrolidone K-25 partially or totally coats the drug:beta-cyclodextrin inclusion complex interacting with the beta-cyclodextrin (through hydrogen bonds), and with the naproxen.

Authors+Show Affiliations

Departamento de Química Física, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12593941

Citation

Valero, Margarita, et al. "Effect of PVP K-25 On the Formation of the Naproxen:beta-ciclodextrin Complex." International Journal of Pharmaceutics, vol. 253, no. 1-2, 2003, pp. 97-110.
Valero M, Pérez-Revuelta BI, Rodríguez LJ. Effect of PVP K-25 on the formation of the naproxen:beta-ciclodextrin complex. Int J Pharm. 2003;253(1-2):97-110.
Valero, M., Pérez-Revuelta, B. I., & Rodríguez, L. J. (2003). Effect of PVP K-25 on the formation of the naproxen:beta-ciclodextrin complex. International Journal of Pharmaceutics, 253(1-2), 97-110.
Valero M, Pérez-Revuelta BI, Rodríguez LJ. Effect of PVP K-25 On the Formation of the Naproxen:beta-ciclodextrin Complex. Int J Pharm. 2003 Mar 6;253(1-2):97-110. PubMed PMID: 12593941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of PVP K-25 on the formation of the naproxen:beta-ciclodextrin complex. AU - Valero,Margarita, AU - Pérez-Revuelta,Blanca I, AU - Rodríguez,Licesio J, PY - 2003/2/21/pubmed PY - 2003/9/27/medline PY - 2003/2/21/entrez SP - 97 EP - 110 JF - International journal of pharmaceutics JO - Int J Pharm VL - 253 IS - 1-2 N2 - The aim of this study was to investigate the effects of the presence of the water-soluble polymer polyvinylpyrrolidone K-25 (MW=24000g/mol) on the complexation of the AINE naproxen, in its sodium salt form, with the beta-cyclodextrin. The data revealed that the polyvinylpyrrolidone K-25 interacts with the drug as well as with the drug:beta-cyclodextrin inclusion complex. The polymer shows more affinity for the inclusion complex, K=(6.67+/-0.292) x 10(-5)M(-1) than for the free drug, (2.08+/-0.208) x 10(-5)M(-1). The presence of different proportions of polymer, in a range 0-1% (w/w) of polyvinylpyrrolidone, does not increase the ability of drug-cyclodextrin complexation but important changes in the driving force of complex formation were detected, depending on the percentage of polyvinylpyrrolidone K-25 present. At low polymer concentrations, the complexation process is driven entropically, while at higher PVP proportions it is enthalpically favored. In the ternary system, polyvinylpyrrolidone K-25 partially or totally coats the drug:beta-cyclodextrin inclusion complex interacting with the beta-cyclodextrin (through hydrogen bonds), and with the naproxen. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/12593941/Effect_of_PVP_K_25_on_the_formation_of_the_naproxen:beta_ciclodextrin_complex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378517302006646 DB - PRIME DP - Unbound Medicine ER -