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Dual sensory innervation of pulmonary neuroepithelial bodies.
Am J Respir Cell Mol Biol 2003; 28(3):275-85AJ

Abstract

The characteristics of the different populations of sensory nerve terminals that selectively contact pulmonary neuroepithelial bodies (NEBs) in rat lungs were investigated after chemical denervation with capsaicin and compared with control lungs. Vagal calbindin D28k and P2X(3) purinoceptor immunoreactive (IR) afferent nerve terminals contacting NEBs appeared to have their origin in the nodose ganglion. Thick CB/P2X(3)-IR nerve fibers were seen to be myelinated and to lose their myelin sheaths just before branching and protruding intraepithelially between the NEB cells. This vagal sensory component of the innervation of NEBs was not affected by capsaicin nor expressed capsaicin receptors (vanilloid receptor subtype 1). A second sensory nerve fiber population that selectively innervates pulmonary NEBs in the rat lung consists of thin unmyelinated nonvagal substance P/calcitonin gene-related peptide IR nerve fibers, contacting mainly the basal pole of pulmonary NEBs, and having their origin in dorsal root ganglia. In concordance with vanilloid receptor 1 expression on these nerve terminals, the spinal sensory substance P/calcitionin gene-related peptide-IR component of the innervation of NEBs was depleted by systemic capsaicin treatment. The complex sensory innervation pattern of pulmonary NEBs characterized in the present study strongly suggests that, physiologically, pulmonary NEBs represent a group of intraepithelial receptors that may be able to accommodate various local and central reflex actions, in relation to both chemo- and mechanosensory stimuli.

Authors+Show Affiliations

Laboratory of Cell Biology and Histology, University of Antwerp-RUCA, Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12594053

Citation

Brouns, Inge, et al. "Dual Sensory Innervation of Pulmonary Neuroepithelial Bodies." American Journal of Respiratory Cell and Molecular Biology, vol. 28, no. 3, 2003, pp. 275-85.
Brouns I, Van Genechten J, Hayashi H, et al. Dual sensory innervation of pulmonary neuroepithelial bodies. Am J Respir Cell Mol Biol. 2003;28(3):275-85.
Brouns, I., Van Genechten, J., Hayashi, H., Gajda, M., Gomi, T., Burnstock, G., ... Adriaensen, D. (2003). Dual sensory innervation of pulmonary neuroepithelial bodies. American Journal of Respiratory Cell and Molecular Biology, 28(3), pp. 275-85.
Brouns I, et al. Dual Sensory Innervation of Pulmonary Neuroepithelial Bodies. Am J Respir Cell Mol Biol. 2003;28(3):275-85. PubMed PMID: 12594053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual sensory innervation of pulmonary neuroepithelial bodies. AU - Brouns,Inge, AU - Van Genechten,Jeroen, AU - Hayashi,Hiroyuki, AU - Gajda,Mariusz, AU - Gomi,Toshiaki, AU - Burnstock,Geoff, AU - Timmermans,Jean-Pierre, AU - Adriaensen,Dirk, PY - 2003/2/21/pubmed PY - 2003/3/20/medline PY - 2003/2/21/entrez SP - 275 EP - 85 JF - American journal of respiratory cell and molecular biology JO - Am. J. Respir. Cell Mol. Biol. VL - 28 IS - 3 N2 - The characteristics of the different populations of sensory nerve terminals that selectively contact pulmonary neuroepithelial bodies (NEBs) in rat lungs were investigated after chemical denervation with capsaicin and compared with control lungs. Vagal calbindin D28k and P2X(3) purinoceptor immunoreactive (IR) afferent nerve terminals contacting NEBs appeared to have their origin in the nodose ganglion. Thick CB/P2X(3)-IR nerve fibers were seen to be myelinated and to lose their myelin sheaths just before branching and protruding intraepithelially between the NEB cells. This vagal sensory component of the innervation of NEBs was not affected by capsaicin nor expressed capsaicin receptors (vanilloid receptor subtype 1). A second sensory nerve fiber population that selectively innervates pulmonary NEBs in the rat lung consists of thin unmyelinated nonvagal substance P/calcitonin gene-related peptide IR nerve fibers, contacting mainly the basal pole of pulmonary NEBs, and having their origin in dorsal root ganglia. In concordance with vanilloid receptor 1 expression on these nerve terminals, the spinal sensory substance P/calcitionin gene-related peptide-IR component of the innervation of NEBs was depleted by systemic capsaicin treatment. The complex sensory innervation pattern of pulmonary NEBs characterized in the present study strongly suggests that, physiologically, pulmonary NEBs represent a group of intraepithelial receptors that may be able to accommodate various local and central reflex actions, in relation to both chemo- and mechanosensory stimuli. SN - 1044-1549 UR - https://www.unboundmedicine.com/medline/citation/12594053/Dual_sensory_innervation_of_pulmonary_neuroepithelial_bodies_ L2 - http://www.atsjournals.org/doi/full/10.1165/rcmb.2002-0117OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -