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Effects of dried fish on antioxidant levels in rat liver.
Indian J Exp Biol 2002; 40(8):914-7IJ

Abstract

Short-term feeding studies were carried out to investigate the effect of ingestion of salted dried fish on alterations in tissue lipid peroxidation and modulation of the activities of detoxification enzymes in liver in order to study the induction of oxidative stress. Rats were fed diets with either 5, 10 and 20% dried mackerel for 4 weeks and levels of antioxidants in liver were estimated. The results showed that the fish intake at 10 and 20% dietary level reduced glutathione with a reciprocal increase in thiobarbituric acid reactive substances and a concomitant decrease in antioxidant vitamins A and C contents in liver. A significant decline in the activities of hepatic glutathione peroxidase and glutathione reductase were also observed at these levels of fish consumption. Kidney gamma-glutamyl transpeptidase activity on the other hand was increased abnormally at 20% fish intake. The results suggested that the dried fish consumption at higher concentrations (at 10 and 20%) for a short period caused lowering of the activities of antioxidative enzymes thereby inducing oxidative stress in rat liver.

Authors+Show Affiliations

Biochemistry & Nutrition Discipline, Defence Food Research Laboratory, Siddhartha Nagar, Mysore 570 011, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12597022

Citation

Anilakumar, K R., et al. "Effects of Dried Fish On Antioxidant Levels in Rat Liver." Indian Journal of Experimental Biology, vol. 40, no. 8, 2002, pp. 914-7.
Anilakumar KR, Khanum F, Krishna KR, et al. Effects of dried fish on antioxidant levels in rat liver. Indian J Exp Biol. 2002;40(8):914-7.
Anilakumar, K. R., Khanum, F., Krishna, K. R., & Viswanathan, K. R. (2002). Effects of dried fish on antioxidant levels in rat liver. Indian Journal of Experimental Biology, 40(8), pp. 914-7.
Anilakumar KR, et al. Effects of Dried Fish On Antioxidant Levels in Rat Liver. Indian J Exp Biol. 2002;40(8):914-7. PubMed PMID: 12597022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dried fish on antioxidant levels in rat liver. AU - Anilakumar,K R, AU - Khanum,Farhath, AU - Krishna,K R Sudarshana, AU - Viswanathan,K R, PY - 2003/2/25/pubmed PY - 2003/4/11/medline PY - 2003/2/25/entrez SP - 914 EP - 7 JF - Indian journal of experimental biology JO - Indian J. Exp. Biol. VL - 40 IS - 8 N2 - Short-term feeding studies were carried out to investigate the effect of ingestion of salted dried fish on alterations in tissue lipid peroxidation and modulation of the activities of detoxification enzymes in liver in order to study the induction of oxidative stress. Rats were fed diets with either 5, 10 and 20% dried mackerel for 4 weeks and levels of antioxidants in liver were estimated. The results showed that the fish intake at 10 and 20% dietary level reduced glutathione with a reciprocal increase in thiobarbituric acid reactive substances and a concomitant decrease in antioxidant vitamins A and C contents in liver. A significant decline in the activities of hepatic glutathione peroxidase and glutathione reductase were also observed at these levels of fish consumption. Kidney gamma-glutamyl transpeptidase activity on the other hand was increased abnormally at 20% fish intake. The results suggested that the dried fish consumption at higher concentrations (at 10 and 20%) for a short period caused lowering of the activities of antioxidative enzymes thereby inducing oxidative stress in rat liver. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/12597022/Effects_of_dried_fish_on_antioxidant_levels_in_rat_liver_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -