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Homocysteine and cognitive function in healthy elderly community dwellers in Italy.
Am J Clin Nutr. 2003 Mar; 77(3):668-73.AJ

Abstract

BACKGROUND

Elevated plasma total homocysteine (tHcy) concentrations are common in the elderly and have been suggested to be a risk factor for dementia.

OBJECTIVE

In an elderly population, we examined the relation between plasma tHcy and scores on the Mini-Mental State Examination (MMSE), a commonly used screening measure of cognitive impairment in general practice.

DESIGN

Fasting plasma tHcy concentrations were measured in 650 healthy, cognitively normal Italian community dwellers aged > or = 65 y (x +/- SD: 72.8 +/- 6.0 y). Socioeconomic status; serum folate, vitamin B-12, and creatinine; other potential dietary and lifestyle determinants of tHcy; and conventional vascular disease risk factors were also assessed.

RESULTS

Subjects with MMSE scores of 26-28 had higher plasma tHcy concentrations (12.7 micromol/L; range: 12.2-13.2 micromol/L) than did those with scores > 28 (11.9 micromol/L; 11.4-12.3 micromol/L; P < 0.01). Subjects with scores of 24-25 had higher plasma tHcy concentrations (14.5 micro mol/L; 13.5-15.6 micromol/L) than did subjects with scores of 26-28 (P < 0.01) or > 28 (P < 0.001). The risk of hyperhomocysteinemia (plasma tHcy > 15 micromol/L) was higher in subjects with scores of 24-25 (odds ratio: 3.81; 95% CI: 1.9, 7.5) or 26-28 (odds ratio: 1.96; 95% CI: 1.3, 3.0) than in those with scores > 28. The results did not change after adjustment for conventional vascular risk factors and for age, medical, dietary, and lifestyle determinants of plasma tHcy.

CONCLUSION

Elevated plasma tHcy has an independent, graded association with concurrent cognitive impairment as measured with the MMSE in healthy elderly community dwellers.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola-Malpighi, Bologna, Italy. ravaglia@almadns.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12600859

Citation

Ravaglia, Giovanni, et al. "Homocysteine and Cognitive Function in Healthy Elderly Community Dwellers in Italy." The American Journal of Clinical Nutrition, vol. 77, no. 3, 2003, pp. 668-73.
Ravaglia G, Forti P, Maioli F, et al. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr. 2003;77(3):668-73.
Ravaglia, G., Forti, P., Maioli, F., Muscari, A., Sacchetti, L., Arnone, G., Nativio, V., Talerico, T., & Mariani, E. (2003). Homocysteine and cognitive function in healthy elderly community dwellers in Italy. The American Journal of Clinical Nutrition, 77(3), 668-73.
Ravaglia G, et al. Homocysteine and Cognitive Function in Healthy Elderly Community Dwellers in Italy. Am J Clin Nutr. 2003;77(3):668-73. PubMed PMID: 12600859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine and cognitive function in healthy elderly community dwellers in Italy. AU - Ravaglia,Giovanni, AU - Forti,Paola, AU - Maioli,Fabiola, AU - Muscari,Antonio, AU - Sacchetti,Loredana, AU - Arnone,Giorgia, AU - Nativio,Valeria, AU - Talerico,Teresa, AU - Mariani,Erminia, PY - 2003/2/26/pubmed PY - 2003/4/16/medline PY - 2003/2/26/entrez SP - 668 EP - 73 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 77 IS - 3 N2 - BACKGROUND: Elevated plasma total homocysteine (tHcy) concentrations are common in the elderly and have been suggested to be a risk factor for dementia. OBJECTIVE: In an elderly population, we examined the relation between plasma tHcy and scores on the Mini-Mental State Examination (MMSE), a commonly used screening measure of cognitive impairment in general practice. DESIGN: Fasting plasma tHcy concentrations were measured in 650 healthy, cognitively normal Italian community dwellers aged > or = 65 y (x +/- SD: 72.8 +/- 6.0 y). Socioeconomic status; serum folate, vitamin B-12, and creatinine; other potential dietary and lifestyle determinants of tHcy; and conventional vascular disease risk factors were also assessed. RESULTS: Subjects with MMSE scores of 26-28 had higher plasma tHcy concentrations (12.7 micromol/L; range: 12.2-13.2 micromol/L) than did those with scores > 28 (11.9 micromol/L; 11.4-12.3 micromol/L; P < 0.01). Subjects with scores of 24-25 had higher plasma tHcy concentrations (14.5 micro mol/L; 13.5-15.6 micromol/L) than did subjects with scores of 26-28 (P < 0.01) or > 28 (P < 0.001). The risk of hyperhomocysteinemia (plasma tHcy > 15 micromol/L) was higher in subjects with scores of 24-25 (odds ratio: 3.81; 95% CI: 1.9, 7.5) or 26-28 (odds ratio: 1.96; 95% CI: 1.3, 3.0) than in those with scores > 28. The results did not change after adjustment for conventional vascular risk factors and for age, medical, dietary, and lifestyle determinants of plasma tHcy. CONCLUSION: Elevated plasma tHcy has an independent, graded association with concurrent cognitive impairment as measured with the MMSE in healthy elderly community dwellers. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12600859/Homocysteine_and_cognitive_function_in_healthy_elderly_community_dwellers_in_Italy_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/77.3.668 DB - PRIME DP - Unbound Medicine ER -