Tags

Type your tag names separated by a space and hit enter

The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds.
Phytother Res. 2003 Feb; 17(2):183-6.PR

Abstract

The effect of an aqueous extract of Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum of Candida albicans produced colonies of the organism in the liver, spleen and kidneys. Treatment of mice with the plant extract (6.6 mL/kg equivalent to 5 mg of estimated protein, once daily for 3 days) 24 h after the inoculation caused a considerable inhibitory effect on the growth of the organism in all organs studied. A 5-fold decrease in Candida in kidneys, 8-fold in liver and 11-fold in spleen was observed in the groups of animals post-treated with the plant extract. Histopathological examination of the respective organs confirmed these findings. These results indicate that the aqueous extract of Nigella sativa seeds exhibits inhibitory effect against candidiasis and this study validates the traditional use of the plant in fungal infections.

Authors+Show Affiliations

Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12601685

Citation

Khan, M A U., et al. "The in Vivo Antifungal Activity of the Aqueous Extract From Nigella Sativa Seeds." Phytotherapy Research : PTR, vol. 17, no. 2, 2003, pp. 183-6.
Khan MA, Ashfaq MK, Zuberi HS, et al. The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res. 2003;17(2):183-6.
Khan, M. A., Ashfaq, M. K., Zuberi, H. S., Mahmood, M. S., & Gilani, A. H. (2003). The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytotherapy Research : PTR, 17(2), 183-6.
Khan MA, et al. The in Vivo Antifungal Activity of the Aqueous Extract From Nigella Sativa Seeds. Phytother Res. 2003;17(2):183-6. PubMed PMID: 12601685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. AU - Khan,M A U, AU - Ashfaq,M K, AU - Zuberi,H S, AU - Mahmood,M S, AU - Gilani,A H, PY - 2003/2/26/pubmed PY - 2003/5/16/medline PY - 2003/2/26/entrez SP - 183 EP - 6 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 2 N2 - The effect of an aqueous extract of Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum of Candida albicans produced colonies of the organism in the liver, spleen and kidneys. Treatment of mice with the plant extract (6.6 mL/kg equivalent to 5 mg of estimated protein, once daily for 3 days) 24 h after the inoculation caused a considerable inhibitory effect on the growth of the organism in all organs studied. A 5-fold decrease in Candida in kidneys, 8-fold in liver and 11-fold in spleen was observed in the groups of animals post-treated with the plant extract. Histopathological examination of the respective organs confirmed these findings. These results indicate that the aqueous extract of Nigella sativa seeds exhibits inhibitory effect against candidiasis and this study validates the traditional use of the plant in fungal infections. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12601685/The_in_vivo_antifungal_activity_of_the_aqueous_extract_from_Nigella_sativa_seeds_ L2 - https://doi.org/10.1002/ptr.1146 DB - PRIME DP - Unbound Medicine ER -