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In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae.
Antimicrob Agents Chemother. 2003 Mar; 47(3):1132-4.AA

Abstract

The bactericidal activities of ABT-773, a new ketolide, were compared to those of cefuroxime and amoxicillin-clavulanate against 10 strains of Streptococcus pneumoniae containing the ermB gene. MICs and time-kill curves were determined in duplicate per NCCLS guidelines with cation-adjusted Mueller-Hinton broth with 3% lysed horse blood. Viable counts were done at 0, 2, 6, and 24 h. Antibiotic concentrations tested were two and eight times the MIC. ABT-773 MICs ranged from 0.008 to 1.0 micro g/ml. Bactericidal activity was observed with ABT-773 at eight times the MIC against 4 of 10 strains at 24 h compared to 10 of 10 strains with the beta-lactam antibiotics.

Authors+Show Affiliations

Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Houston, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12604554

Citation

Neuhauser, Melinda M., et al. "In Vitro Bactericidal Activities of ABT-773 Against ermB Strains of Streptococcus Pneumoniae." Antimicrobial Agents and Chemotherapy, vol. 47, no. 3, 2003, pp. 1132-4.
Neuhauser MM, Prause JL, Danziger LH, et al. In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2003;47(3):1132-4.
Neuhauser, M. M., Prause, J. L., Danziger, L. H., & Pendland, S. L. (2003). In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 47(3), 1132-4.
Neuhauser MM, et al. In Vitro Bactericidal Activities of ABT-773 Against ermB Strains of Streptococcus Pneumoniae. Antimicrob Agents Chemother. 2003;47(3):1132-4. PubMed PMID: 12604554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae. AU - Neuhauser,Melinda M, AU - Prause,Jennifer L, AU - Danziger,Larry H, AU - Pendland,Susan L, PY - 2003/2/27/pubmed PY - 2003/8/15/medline PY - 2003/2/27/entrez SP - 1132 EP - 4 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 47 IS - 3 N2 - The bactericidal activities of ABT-773, a new ketolide, were compared to those of cefuroxime and amoxicillin-clavulanate against 10 strains of Streptococcus pneumoniae containing the ermB gene. MICs and time-kill curves were determined in duplicate per NCCLS guidelines with cation-adjusted Mueller-Hinton broth with 3% lysed horse blood. Viable counts were done at 0, 2, 6, and 24 h. Antibiotic concentrations tested were two and eight times the MIC. ABT-773 MICs ranged from 0.008 to 1.0 micro g/ml. Bactericidal activity was observed with ABT-773 at eight times the MIC against 4 of 10 strains at 24 h compared to 10 of 10 strains with the beta-lactam antibiotics. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/12604554/In_vitro_bactericidal_activities_of_ABT_773_against_ermB_strains_of_Streptococcus_pneumoniae_ L2 - https://journals.asm.org/doi/10.1128/AAC.47.3.1132-1134.2003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -