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Antinociceptive synergy between delta(9)-tetrahydrocannabinol and opioids after oral administration.
J Pharmacol Exp Ther. 2003 Mar; 304(3):1010-5.JP

Abstract

The analgesic effects of opioids, such as morphine and codeine, in mice are enhanced by oral administration of the cannabinoid delta(9)-tetrahydrocannabinol (delta(9)-THC). However, isobolographic analysis has never been done to confirm a synergy between delta(9)-THC and morphine or codeine via oral routes of administration. To determine the nature of the interaction between these drugs for pain relief and extend previous experimental results, we performed an isobolographic analysis to evaluate for additivity or synergy in the tail-flick test. Fixed-ratio combinations of delta(9)-THC with either morphine or codeine were tested for antinociceptive effects. The experimentally derived ED(50) for each combination was compared with the theoretical additive ED(50), using an isobolographic analysis. All of the fixed-ratio combinations tested produced greater antinociception (synergy) than predicted from simple additivity. These findings suggest that the use of a low-dose combination of analgesics is a valid and effective approach for the treatment of pain and necessitates further study.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA. dcichewi@hsc.vcu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12604676

Citation

Cichewicz, Diana L., and Erin A. McCarthy. "Antinociceptive Synergy Between Delta(9)-tetrahydrocannabinol and Opioids After Oral Administration." The Journal of Pharmacology and Experimental Therapeutics, vol. 304, no. 3, 2003, pp. 1010-5.
Cichewicz DL, McCarthy EA. Antinociceptive synergy between delta(9)-tetrahydrocannabinol and opioids after oral administration. J Pharmacol Exp Ther. 2003;304(3):1010-5.
Cichewicz, D. L., & McCarthy, E. A. (2003). Antinociceptive synergy between delta(9)-tetrahydrocannabinol and opioids after oral administration. The Journal of Pharmacology and Experimental Therapeutics, 304(3), 1010-5.
Cichewicz DL, McCarthy EA. Antinociceptive Synergy Between Delta(9)-tetrahydrocannabinol and Opioids After Oral Administration. J Pharmacol Exp Ther. 2003;304(3):1010-5. PubMed PMID: 12604676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive synergy between delta(9)-tetrahydrocannabinol and opioids after oral administration. AU - Cichewicz,Diana L, AU - McCarthy,Erin A, PY - 2003/2/27/pubmed PY - 2003/4/22/medline PY - 2003/2/27/entrez SP - 1010 EP - 5 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 304 IS - 3 N2 - The analgesic effects of opioids, such as morphine and codeine, in mice are enhanced by oral administration of the cannabinoid delta(9)-tetrahydrocannabinol (delta(9)-THC). However, isobolographic analysis has never been done to confirm a synergy between delta(9)-THC and morphine or codeine via oral routes of administration. To determine the nature of the interaction between these drugs for pain relief and extend previous experimental results, we performed an isobolographic analysis to evaluate for additivity or synergy in the tail-flick test. Fixed-ratio combinations of delta(9)-THC with either morphine or codeine were tested for antinociceptive effects. The experimentally derived ED(50) for each combination was compared with the theoretical additive ED(50), using an isobolographic analysis. All of the fixed-ratio combinations tested produced greater antinociception (synergy) than predicted from simple additivity. These findings suggest that the use of a low-dose combination of analgesics is a valid and effective approach for the treatment of pain and necessitates further study. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/12604676/Antinociceptive_synergy_between_delta_9__tetrahydrocannabinol_and_opioids_after_oral_administration_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12604676 DB - PRIME DP - Unbound Medicine ER -