Tags

Type your tag names separated by a space and hit enter

Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin.
Am J Hematol. 2003 Mar; 72(3):220-2.AJ

Abstract

A male patient had a relapse of myelodysplastic syndrome (MDS) 2 years after BMT from a female matched unrelated donor. Conventional cytogenetics, FISH, and short-tandem repeat chimerism analysis proved a relapse of donor origin. He underwent reduced-intensity BMT after a conditioning with fludarabine and busulfan, since he had impaired renal, liver, and pulmonary functions. Chimerism analysis on day 28 after the second BMT showed mixed chimerism of the first and the second donors, which later turned to full second-donor chimerism on day 60. He developed grade II acute GVHD of the skin and cytomegalovirus reactivation, but both were improved with methylprednisolone and ganciclovir, respectively. He remains in complete remission 6 months after the second BMT. Reduced-intensity second BMT from an alternative donor appeared to be a tolerable treatment option for donor-derived leukemia/MDS after the first conventional transplantation.

Authors+Show Affiliations

Department of Cell Therapy & Transplantation Medicine, University of Tokyo Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12605397

Citation

Komeno, Yukiko, et al. "Reduced-intensity Bone Marrow Transplantation From an Alternative Unrelated Donor for Myelodysplastic Syndrome of First-donor Origin." American Journal of Hematology, vol. 72, no. 3, 2003, pp. 220-2.
Komeno Y, Kanda Y, Kandabashi K, et al. Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin. Am J Hematol. 2003;72(3):220-2.
Komeno, Y., Kanda, Y., Kandabashi, K., Kawazu, M., Goyama, S., Takeshita, M., Nannya, Y., Niino, M., Nakamoto, T., Kurokawa, M., Tsujino, S., Ogawa, S., Aoki, K., Chiba, S., Motokura, T., & Hirai, H. (2003). Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin. American Journal of Hematology, 72(3), 220-2.
Komeno Y, et al. Reduced-intensity Bone Marrow Transplantation From an Alternative Unrelated Donor for Myelodysplastic Syndrome of First-donor Origin. Am J Hematol. 2003;72(3):220-2. PubMed PMID: 12605397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin. AU - Komeno,Yukiko, AU - Kanda,Yoshinobu, AU - Kandabashi,Koji, AU - Kawazu,Masahito, AU - Goyama,Susumu, AU - Takeshita,Masataka, AU - Nannya,Yasuhito, AU - Niino,Miyuki, AU - Nakamoto,Tetsuya, AU - Kurokawa,Mineo, AU - Tsujino,Shiho, AU - Ogawa,Seishi, AU - Aoki,Katsunori, AU - Chiba,Shigeru, AU - Motokura,Toru, AU - Hirai,Hisamaru, PY - 2003/2/28/pubmed PY - 2003/3/22/medline PY - 2003/2/28/entrez SP - 220 EP - 2 JF - American journal of hematology JO - Am J Hematol VL - 72 IS - 3 N2 - A male patient had a relapse of myelodysplastic syndrome (MDS) 2 years after BMT from a female matched unrelated donor. Conventional cytogenetics, FISH, and short-tandem repeat chimerism analysis proved a relapse of donor origin. He underwent reduced-intensity BMT after a conditioning with fludarabine and busulfan, since he had impaired renal, liver, and pulmonary functions. Chimerism analysis on day 28 after the second BMT showed mixed chimerism of the first and the second donors, which later turned to full second-donor chimerism on day 60. He developed grade II acute GVHD of the skin and cytomegalovirus reactivation, but both were improved with methylprednisolone and ganciclovir, respectively. He remains in complete remission 6 months after the second BMT. Reduced-intensity second BMT from an alternative donor appeared to be a tolerable treatment option for donor-derived leukemia/MDS after the first conventional transplantation. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/12605397/Reduced_intensity_bone_marrow_transplantation_from_an_alternative_unrelated_donor_for_myelodysplastic_syndrome_of_first_donor_origin_ L2 - https://doi.org/10.1002/ajh.10286 DB - PRIME DP - Unbound Medicine ER -