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Genetic alterations in pancreatic carcinoma.

Abstract

Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year survival rate under 5%. Our understanding of the molecular carcinogenesis has improved in the last few years due to the development of novel molecular biological techniques. Pancreatic cancer is a multi-stage process resulting from the accumulation of genetic changes in the somatic DNA of normal cells. In this article we describe major genetic alterations of pancreatic cancer, mutations in the proto-oncogene K-RAS and the tumor suppressors INK4A, TP53 and DPC4/SMAD4. The accumulation of these genetic changes leads to a profound disturbance in cell cycle regulation and continuous growth. The knowledge of the underlying molecular mechanisms will offer new therapeutic and diagnostic options and hopefully improve the outcome of this aggressive disease.

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  • Authors+Show Affiliations

    ,

    Klinikum rechts der Isar, II. Department of Internal Medicine, Ismaningerstr. 22, D-81675 Munich, Germany. guenter.schneider@lrz.tum.de

    Source

    Molecular cancer 2: 2003 Jan 22 pg 15

    MeSH

    Animals
    Apoptosis
    Cyclin-Dependent Kinase Inhibitor p16
    DNA-Binding Proteins
    G1 Phase
    Genes, ras
    Humans
    Models, Biological
    Mutation
    Pancreatic Neoplasms
    Smad4 Protein
    Trans-Activators
    Tumor Suppressor Protein p53

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12605716

    Citation

    Schneider, Gunter, and Roland M. Schmid. "Genetic Alterations in Pancreatic Carcinoma." Molecular Cancer, vol. 2, 2003, p. 15.
    Schneider G, Schmid RM. Genetic alterations in pancreatic carcinoma. Mol Cancer. 2003;2:15.
    Schneider, G., & Schmid, R. M. (2003). Genetic alterations in pancreatic carcinoma. Molecular Cancer, 2, p. 15.
    Schneider G, Schmid RM. Genetic Alterations in Pancreatic Carcinoma. Mol Cancer. 2003 Jan 22;2:15. PubMed PMID: 12605716.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genetic alterations in pancreatic carcinoma. AU - Schneider,Gunter, AU - Schmid,Roland M, Y1 - 2003/01/22/ PY - 2002/12/27/received PY - 2003/01/22/accepted PY - 2003/2/28/pubmed PY - 2004/11/16/medline PY - 2003/2/28/entrez SP - 15 EP - 15 JF - Molecular cancer JO - Mol. Cancer VL - 2 N2 - Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year survival rate under 5%. Our understanding of the molecular carcinogenesis has improved in the last few years due to the development of novel molecular biological techniques. Pancreatic cancer is a multi-stage process resulting from the accumulation of genetic changes in the somatic DNA of normal cells. In this article we describe major genetic alterations of pancreatic cancer, mutations in the proto-oncogene K-RAS and the tumor suppressors INK4A, TP53 and DPC4/SMAD4. The accumulation of these genetic changes leads to a profound disturbance in cell cycle regulation and continuous growth. The knowledge of the underlying molecular mechanisms will offer new therapeutic and diagnostic options and hopefully improve the outcome of this aggressive disease. SN - 1476-4598 UR - https://www.unboundmedicine.com/medline/citation/12605716/Genetic_alterations_in_pancreatic_carcinoma_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/12605716/ DB - PRIME DP - Unbound Medicine ER -