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Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus.
Biol Reprod. 2003 May; 68(5):1703-10.BR

Abstract

Major histocompatibility complex (MHC) class I molecules, consisting of an alpha chain and beta2-microglobulin (beta2MG), play an important role in immune rejection responses by discriminating self and nonself and are increased by type I interferons during antiviral responses. Interferon tau (IFNtau), the pregnancy-recognition signal in ruminants, is a type I interferon produced by the ovine conceptus between Days 11 and 21 of gestation. In study 1, expression of MHC class I alpha chain and beta2MG mRNA and protein was detected primarily in endometrial luminal epithelium (LE) and glandular epithelium (GE) on Days 10 and 12 of the estrous cycle and pregnancy. On Days 14-20 of pregnancy, MHC class I and beta2MG expression increased only in endometrial stroma and GE and, concurrently, was absent in LE and superficial ductal GE (sGE). Although neither MHC class I nor beta2MG proteins were detected in Day 20 trophectoderm, beta2MG mRNA was detected in conceptus trophectoderm. In study 2, cyclic ewes were ovariectomized on Day 5, treated daily with progesterone to Day 16, received intrauterine infusions between Days 11 and 16 of either control serum proteins or recombinant ovine IFNtau, and were hysterectomized on Day 17. The IFNtau increased MHC class I and beta2MG expression only in endometrial stroma and GE. During pregnancy, MHC class I and beta2MG gene expression is inhibited in endometrial LE and sGE but, paradoxically, is stimulated by IFNtau in the stroma and GE. The silencing of MHC class I alpha chain and beta2MG genes in the endometrial LE and sGE during pregnancy recognition and establishment may be a critical mechanism preventing immune rejection of the conceptus allograft.

Authors+Show Affiliations

Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A&M University, College Station 77843, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12606392

Citation

Choi, Youngsok, et al. "Pregnancy and Interferon Tau Regulate Major Histocompatibility Complex Class I and Beta2-microglobulin Expression in the Ovine Uterus." Biology of Reproduction, vol. 68, no. 5, 2003, pp. 1703-10.
Choi Y, Johnson GA, Spencer TE, et al. Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus. Biol Reprod. 2003;68(5):1703-10.
Choi, Y., Johnson, G. A., Spencer, T. E., & Bazer, F. W. (2003). Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus. Biology of Reproduction, 68(5), 1703-10.
Choi Y, et al. Pregnancy and Interferon Tau Regulate Major Histocompatibility Complex Class I and Beta2-microglobulin Expression in the Ovine Uterus. Biol Reprod. 2003;68(5):1703-10. PubMed PMID: 12606392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus. AU - Choi,Youngsok, AU - Johnson,Greg A, AU - Spencer,Thomas E, AU - Bazer,Fuller W, Y1 - 2002/12/11/ PY - 2003/2/28/pubmed PY - 2003/12/13/medline PY - 2003/2/28/entrez SP - 1703 EP - 10 JF - Biology of reproduction JO - Biol. Reprod. VL - 68 IS - 5 N2 - Major histocompatibility complex (MHC) class I molecules, consisting of an alpha chain and beta2-microglobulin (beta2MG), play an important role in immune rejection responses by discriminating self and nonself and are increased by type I interferons during antiviral responses. Interferon tau (IFNtau), the pregnancy-recognition signal in ruminants, is a type I interferon produced by the ovine conceptus between Days 11 and 21 of gestation. In study 1, expression of MHC class I alpha chain and beta2MG mRNA and protein was detected primarily in endometrial luminal epithelium (LE) and glandular epithelium (GE) on Days 10 and 12 of the estrous cycle and pregnancy. On Days 14-20 of pregnancy, MHC class I and beta2MG expression increased only in endometrial stroma and GE and, concurrently, was absent in LE and superficial ductal GE (sGE). Although neither MHC class I nor beta2MG proteins were detected in Day 20 trophectoderm, beta2MG mRNA was detected in conceptus trophectoderm. In study 2, cyclic ewes were ovariectomized on Day 5, treated daily with progesterone to Day 16, received intrauterine infusions between Days 11 and 16 of either control serum proteins or recombinant ovine IFNtau, and were hysterectomized on Day 17. The IFNtau increased MHC class I and beta2MG expression only in endometrial stroma and GE. During pregnancy, MHC class I and beta2MG gene expression is inhibited in endometrial LE and sGE but, paradoxically, is stimulated by IFNtau in the stroma and GE. The silencing of MHC class I alpha chain and beta2MG genes in the endometrial LE and sGE during pregnancy recognition and establishment may be a critical mechanism preventing immune rejection of the conceptus allograft. SN - 0006-3363 UR - https://www.unboundmedicine.com/medline/citation/12606392/Pregnancy_and_interferon_tau_regulate_major_histocompatibility_complex_class_I_and_beta2_microglobulin_expression_in_the_ovine_uterus_ L2 - https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod.102.012708 DB - PRIME DP - Unbound Medicine ER -