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Infection with Chlamydia pneumoniae and risk of multiple sclerosis.
Epidemiology 2003; 14(2):141-7E

Abstract

BACKGROUND

Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent for multiple sclerosis (MS), but results of previous studies are conflicting.

METHODS

Using a nested case-control design, we examined the association between Cpn infection and MS in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II) cohorts. Among 32,826 women in the NHS and 29,722 women in the NHS II with blood samples, 141 incident cases of definite or probable MS were documented. Each case was matched to two healthy controls on year of birth and NHS cohort. Serum samples were tested for the presence of Cpn-specific immunoglobin G antibodies using microimmunofluorescence.

RESULTS

Cpn immunoglobin G seropositivity was positively associated with risk of MS (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.1-2.7). This association did not change after adjusting for age at blood collection, ancestry, latitude of residence at birth, and smoking (OR = 1.9; CI = 1.1-3.1). Seropositivity for Cpn was only moderately associated with risk of relapsing-remitting MS (OR = 1.7; CI = 0.9-3.2), but it was strongly associated with risk of progressive MS (OR = 7.3; CI = 1.4-37.2). Geometric mean titers of Cpn-specific immunoglobin G antibody were similar in women with relapsing-remitting MS as compared with matched controls (44 vs 39), but they were elevated in women with progressive MS (99 vs 40).

CONCLUSIONS

These results support a positive association between Cpn infection and progressive MS.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12606878

Citation

Munger, Kassandra L., et al. "Infection With Chlamydia Pneumoniae and Risk of Multiple Sclerosis." Epidemiology (Cambridge, Mass.), vol. 14, no. 2, 2003, pp. 141-7.
Munger KL, Peeling RW, Hernán MA, et al. Infection with Chlamydia pneumoniae and risk of multiple sclerosis. Epidemiology. 2003;14(2):141-7.
Munger, K. L., Peeling, R. W., Hernán, M. A., Chasan-Taber, L., Olek, M. J., Hankinson, S. E., ... Ascherio, A. (2003). Infection with Chlamydia pneumoniae and risk of multiple sclerosis. Epidemiology (Cambridge, Mass.), 14(2), pp. 141-7.
Munger KL, et al. Infection With Chlamydia Pneumoniae and Risk of Multiple Sclerosis. Epidemiology. 2003;14(2):141-7. PubMed PMID: 12606878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infection with Chlamydia pneumoniae and risk of multiple sclerosis. AU - Munger,Kassandra L, AU - Peeling,Rosanna W, AU - Hernán,Miguel A, AU - Chasan-Taber,Lisa, AU - Olek,Michael J, AU - Hankinson,Susan E, AU - Hunter,David, AU - Ascherio,Alberto, PY - 2003/2/28/pubmed PY - 2003/6/11/medline PY - 2003/2/28/entrez SP - 141 EP - 7 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 14 IS - 2 N2 - BACKGROUND: Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent for multiple sclerosis (MS), but results of previous studies are conflicting. METHODS: Using a nested case-control design, we examined the association between Cpn infection and MS in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II) cohorts. Among 32,826 women in the NHS and 29,722 women in the NHS II with blood samples, 141 incident cases of definite or probable MS were documented. Each case was matched to two healthy controls on year of birth and NHS cohort. Serum samples were tested for the presence of Cpn-specific immunoglobin G antibodies using microimmunofluorescence. RESULTS: Cpn immunoglobin G seropositivity was positively associated with risk of MS (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.1-2.7). This association did not change after adjusting for age at blood collection, ancestry, latitude of residence at birth, and smoking (OR = 1.9; CI = 1.1-3.1). Seropositivity for Cpn was only moderately associated with risk of relapsing-remitting MS (OR = 1.7; CI = 0.9-3.2), but it was strongly associated with risk of progressive MS (OR = 7.3; CI = 1.4-37.2). Geometric mean titers of Cpn-specific immunoglobin G antibody were similar in women with relapsing-remitting MS as compared with matched controls (44 vs 39), but they were elevated in women with progressive MS (99 vs 40). CONCLUSIONS: These results support a positive association between Cpn infection and progressive MS. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/12606878/Infection_with_Chlamydia_pneumoniae_and_risk_of_multiple_sclerosis_ L2 - http://Insights.ovid.com/pubmed?pmid=12606878 DB - PRIME DP - Unbound Medicine ER -