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Infection with Chlamydia pneumoniae and risk of multiple sclerosis.

Abstract

BACKGROUND

Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent for multiple sclerosis (MS), but results of previous studies are conflicting.

METHODS

Using a nested case-control design, we examined the association between Cpn infection and MS in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II) cohorts. Among 32,826 women in the NHS and 29,722 women in the NHS II with blood samples, 141 incident cases of definite or probable MS were documented. Each case was matched to two healthy controls on year of birth and NHS cohort. Serum samples were tested for the presence of Cpn-specific immunoglobin G antibodies using microimmunofluorescence.

RESULTS

Cpn immunoglobin G seropositivity was positively associated with risk of MS (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.1-2.7). This association did not change after adjusting for age at blood collection, ancestry, latitude of residence at birth, and smoking (OR = 1.9; CI = 1.1-3.1). Seropositivity for Cpn was only moderately associated with risk of relapsing-remitting MS (OR = 1.7; CI = 0.9-3.2), but it was strongly associated with risk of progressive MS (OR = 7.3; CI = 1.4-37.2). Geometric mean titers of Cpn-specific immunoglobin G antibody were similar in women with relapsing-remitting MS as compared with matched controls (44 vs 39), but they were elevated in women with progressive MS (99 vs 40).

CONCLUSIONS

These results support a positive association between Cpn infection and progressive MS.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

    , , , , , ,

    Source

    Epidemiology (Cambridge, Mass.) 14:2 2003 Mar pg 141-7

    MeSH

    Adult
    Antibodies, Bacterial
    Case-Control Studies
    Chlamydia Infections
    Chlamydophila pneumoniae
    Female
    Humans
    Immunoglobulin G
    Incidence
    Logistic Models
    Middle Aged
    Multiple Sclerosis
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12606878

    Citation

    Munger, Kassandra L., et al. "Infection With Chlamydia Pneumoniae and Risk of Multiple Sclerosis." Epidemiology (Cambridge, Mass.), vol. 14, no. 2, 2003, pp. 141-7.
    Munger KL, Peeling RW, Hernán MA, et al. Infection with Chlamydia pneumoniae and risk of multiple sclerosis. Epidemiology. 2003;14(2):141-7.
    Munger, K. L., Peeling, R. W., Hernán, M. A., Chasan-Taber, L., Olek, M. J., Hankinson, S. E., ... Ascherio, A. (2003). Infection with Chlamydia pneumoniae and risk of multiple sclerosis. Epidemiology (Cambridge, Mass.), 14(2), pp. 141-7.
    Munger KL, et al. Infection With Chlamydia Pneumoniae and Risk of Multiple Sclerosis. Epidemiology. 2003;14(2):141-7. PubMed PMID: 12606878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Infection with Chlamydia pneumoniae and risk of multiple sclerosis. AU - Munger,Kassandra L, AU - Peeling,Rosanna W, AU - Hernán,Miguel A, AU - Chasan-Taber,Lisa, AU - Olek,Michael J, AU - Hankinson,Susan E, AU - Hunter,David, AU - Ascherio,Alberto, PY - 2003/2/28/pubmed PY - 2003/6/11/medline PY - 2003/2/28/entrez SP - 141 EP - 7 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 14 IS - 2 N2 - BACKGROUND: Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent for multiple sclerosis (MS), but results of previous studies are conflicting. METHODS: Using a nested case-control design, we examined the association between Cpn infection and MS in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II) cohorts. Among 32,826 women in the NHS and 29,722 women in the NHS II with blood samples, 141 incident cases of definite or probable MS were documented. Each case was matched to two healthy controls on year of birth and NHS cohort. Serum samples were tested for the presence of Cpn-specific immunoglobin G antibodies using microimmunofluorescence. RESULTS: Cpn immunoglobin G seropositivity was positively associated with risk of MS (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.1-2.7). This association did not change after adjusting for age at blood collection, ancestry, latitude of residence at birth, and smoking (OR = 1.9; CI = 1.1-3.1). Seropositivity for Cpn was only moderately associated with risk of relapsing-remitting MS (OR = 1.7; CI = 0.9-3.2), but it was strongly associated with risk of progressive MS (OR = 7.3; CI = 1.4-37.2). Geometric mean titers of Cpn-specific immunoglobin G antibody were similar in women with relapsing-remitting MS as compared with matched controls (44 vs 39), but they were elevated in women with progressive MS (99 vs 40). CONCLUSIONS: These results support a positive association between Cpn infection and progressive MS. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/12606878/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=12606878 DB - PRIME DP - Unbound Medicine ER -