Tags

Type your tag names separated by a space and hit enter

Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp.
J Nat Prod. 2003 Feb; 66(2):272-5.JN

Abstract

Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity.

Authors+Show Affiliations

Schupp P
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
Poehner T
No affiliation info available
Edrada R
No affiliation info available
Ebel R
No affiliation info available
Berg A
No affiliation info available
Wray V
No affiliation info available
Proksch P
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntifungal AgentsBacillus subtilisCandida albicansCarbolinesEscherichia coliMicronesiaMolecular StructureNuclear Magnetic Resonance, BiomolecularSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusUrochordata

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12608864

Citation

Schupp, Peter, et al. "Eudistomins W and X, Two New Beta-carbolines From the Micronesian Tunicate Eudistoma Sp." Journal of Natural Products, vol. 66, no. 2, 2003, pp. 272-5.
Schupp P, Poehner T, Edrada R, et al. Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp. J Nat Prod. 2003;66(2):272-5.
Schupp, P., Poehner, T., Edrada, R., Ebel, R., Berg, A., Wray, V., & Proksch, P. (2003). Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp. Journal of Natural Products, 66(2), 272-5.
Schupp P, et al. Eudistomins W and X, Two New Beta-carbolines From the Micronesian Tunicate Eudistoma Sp. J Nat Prod. 2003;66(2):272-5. PubMed PMID: 12608864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp. AU - Schupp,Peter, AU - Poehner,Timo, AU - Edrada,RuAngelie, AU - Ebel,Rainer, AU - Berg,Albrecht, AU - Wray,Victor, AU - Proksch,Peter, PY - 2003/3/1/pubmed PY - 2003/7/8/medline PY - 2003/3/1/entrez SP - 272 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 2 N2 - Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/12608864/Eudistomins_W_and_X_two_new_beta_carbolines_from_the_micronesian_tunicate_Eudistoma_sp_ DB - PRIME DP - Unbound Medicine ER -