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Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol.
Eur J Dermatol. 2003 Jan-Feb; 13(1):40-3.EJ

Abstract

Cutaneous leishmaniasis (CL) is endemic in many countries. It has been recognized as a major public health problem in Iran. The pentavalent antimonials are the first line drugs for the treatment of CL. Recently strains resistant to these drugs have been reported. Allopurinol (AL) has also been suggested for treatment of CL. The efficacy of combination of AL and meglumine antimoniate (MA) in treatment of non-healing cases of CL was evaluated. Non-healing cases of CL have been treated with combination of AL (20 mg/kg for 30 days) and meglumine antimoniate (60 mg/kg per day for 20 days). Twenty-six patients with lupoid leishmaniasis, 6 patients with chronic leishmaniasis and 5 patients who had unhealed leishmaniasis due to leishmanization were accepted for the study. All of the patients except two responded well to treatment, no side effects have been observed and a two year follow up showed no recurrence. A combination of AL and MA increase the antileishmanial effects of antimoniate. We suggest this combination therapy for non-healing and resistant cases of CL.

Authors+Show Affiliations

Aminjavaheri Medical Lab. P.O. Box 1191, 81465 Isfahan, Iran. azmomeni@iranmedical.comNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Journal Article

Language

eng

PubMed ID

12609780

Citation

Momeni, Ali Z., and Malihalsadat Aminjavaheri. "Successful Treatment of Non-healing Cases of Cutaneous Leishmaniasis, Using a Combination of Meglumine Antimoniate Plus Allopurinol." European Journal of Dermatology : EJD, vol. 13, no. 1, 2003, pp. 40-3.
Momeni AZ, Aminjavaheri M. Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol. Eur J Dermatol. 2003;13(1):40-3.
Momeni, A. Z., & Aminjavaheri, M. (2003). Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol. European Journal of Dermatology : EJD, 13(1), 40-3.
Momeni AZ, Aminjavaheri M. Successful Treatment of Non-healing Cases of Cutaneous Leishmaniasis, Using a Combination of Meglumine Antimoniate Plus Allopurinol. Eur J Dermatol. 2003 Jan-Feb;13(1):40-3. PubMed PMID: 12609780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol. AU - Momeni,Ali Z, AU - Aminjavaheri,Malihalsadat, PY - 2003/3/1/pubmed PY - 2003/6/5/medline PY - 2003/3/1/entrez SP - 40 EP - 3 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 13 IS - 1 N2 - Cutaneous leishmaniasis (CL) is endemic in many countries. It has been recognized as a major public health problem in Iran. The pentavalent antimonials are the first line drugs for the treatment of CL. Recently strains resistant to these drugs have been reported. Allopurinol (AL) has also been suggested for treatment of CL. The efficacy of combination of AL and meglumine antimoniate (MA) in treatment of non-healing cases of CL was evaluated. Non-healing cases of CL have been treated with combination of AL (20 mg/kg for 30 days) and meglumine antimoniate (60 mg/kg per day for 20 days). Twenty-six patients with lupoid leishmaniasis, 6 patients with chronic leishmaniasis and 5 patients who had unhealed leishmaniasis due to leishmanization were accepted for the study. All of the patients except two responded well to treatment, no side effects have been observed and a two year follow up showed no recurrence. A combination of AL and MA increase the antileishmanial effects of antimoniate. We suggest this combination therapy for non-healing and resistant cases of CL. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/12609780/Successful_treatment_of_non_healing_cases_of_cutaneous_leishmaniasis_using_a_combination_of_meglumine_antimoniate_plus_allopurinol_ DB - PRIME DP - Unbound Medicine ER -