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A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.
J Rheumatol. 2003 Mar; 30(3):523-8.JR

Abstract

OBJECTIVE

To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee.

METHODS

Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire.

RESULTS

VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change -3.4 cm, SD 2.6 cm) compared to the placebo group (mean change -1.6 cm, SD 2.7 cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95% CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95% CI for difference between groups, 0.6 to 2.9 cm; p = 0.002).

CONCLUSION

Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks.

Authors+Show Affiliations

Department of Complementary Medicine, Faculty of Life Sciences, RMIT University, Bundoora, Australia. marc.cohen@rmit.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12610812

Citation

Cohen, Marc, et al. "A Randomized, Double Blind, Placebo Controlled Trial of a Topical Cream Containing Glucosamine Sulfate, Chondroitin Sulfate, and Camphor for Osteoarthritis of the Knee." The Journal of Rheumatology, vol. 30, no. 3, 2003, pp. 523-8.
Cohen M, Wolfe R, Mai T, et al. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol. 2003;30(3):523-8.
Cohen, M., Wolfe, R., Mai, T., & Lewis, D. (2003). A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. The Journal of Rheumatology, 30(3), 523-8.
Cohen M, et al. A Randomized, Double Blind, Placebo Controlled Trial of a Topical Cream Containing Glucosamine Sulfate, Chondroitin Sulfate, and Camphor for Osteoarthritis of the Knee. J Rheumatol. 2003;30(3):523-8. PubMed PMID: 12610812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. AU - Cohen,Marc, AU - Wolfe,Rory, AU - Mai,Trudy, AU - Lewis,Daniel, PY - 2003/3/1/pubmed PY - 2003/6/19/medline PY - 2003/3/1/entrez SP - 523 EP - 8 JF - The Journal of rheumatology JO - J Rheumatol VL - 30 IS - 3 N2 - OBJECTIVE: To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee. METHODS: Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire. RESULTS: VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change -3.4 cm, SD 2.6 cm) compared to the placebo group (mean change -1.6 cm, SD 2.7 cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95% CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95% CI for difference between groups, 0.6 to 2.9 cm; p = 0.002). CONCLUSION: Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/12610812/A_randomized_double_blind_placebo_controlled_trial_of_a_topical_cream_containing_glucosamine_sulfate_chondroitin_sulfate_and_camphor_for_osteoarthritis_of_the_knee_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=12610812 DB - PRIME DP - Unbound Medicine ER -