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Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats.
Pharmazie. 2002 Nov; 57(11):758-60.P

Abstract

The present study was carried out to evaluate the antihyperglycaemic effect of Casearia esculenta root extract and to study the activities of liver hexokinase and gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase in liver and kidney of normal and streptozotocin-induced diabetic rats. Oral administration of aqueous extract of root (300 mg/kg body weight) for 45 days resulted in a significant reduction in blood glucose from 250.79 +/- 12.65 to 135.70 +/- 8.90 and in a decrease in the activities of glucose-6-phosphatase and fructose-1,6-bishosphatase and an increase in the activity of liver hexokinase. However, in the case of 200 mg/kg body weight of extract, less activity was observed. The study clearly shows that the root extract of C. esculenta possesses potent antihyperglycaemic activity but weaker than that of glibenclamide.

Authors+Show Affiliations

Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12611280

Citation

Prakasam, A, et al. "Antihyperglycaemic Effect of Casearia Esculenta Root Extracts in Streptozotocin-induced Diabetic Rats." Die Pharmazie, vol. 57, no. 11, 2002, pp. 758-60.
Prakasam A, Sethupathy S, Pugalendi KV. Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Pharmazie. 2002;57(11):758-60.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2002). Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Die Pharmazie, 57(11), 758-60.
Prakasam A, Sethupathy S, Pugalendi KV. Antihyperglycaemic Effect of Casearia Esculenta Root Extracts in Streptozotocin-induced Diabetic Rats. Pharmazie. 2002;57(11):758-60. PubMed PMID: 12611280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. AU - Prakasam,A, AU - Sethupathy,S, AU - Pugalendi,K V, PY - 2003/3/4/pubmed PY - 2003/4/1/medline PY - 2003/3/4/entrez SP - 758 EP - 60 JF - Die Pharmazie JO - Pharmazie VL - 57 IS - 11 N2 - The present study was carried out to evaluate the antihyperglycaemic effect of Casearia esculenta root extract and to study the activities of liver hexokinase and gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase in liver and kidney of normal and streptozotocin-induced diabetic rats. Oral administration of aqueous extract of root (300 mg/kg body weight) for 45 days resulted in a significant reduction in blood glucose from 250.79 +/- 12.65 to 135.70 +/- 8.90 and in a decrease in the activities of glucose-6-phosphatase and fructose-1,6-bishosphatase and an increase in the activity of liver hexokinase. However, in the case of 200 mg/kg body weight of extract, less activity was observed. The study clearly shows that the root extract of C. esculenta possesses potent antihyperglycaemic activity but weaker than that of glibenclamide. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/12611280/Antihyperglycaemic_effect_of_Casearia_esculenta_root_extracts_in_streptozotocin_induced_diabetic_rats_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -