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Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia in offspring?
Am J Psychiatry 2003; 160(3):464-8AJ

Abstract

OBJECTIVE

Diuretics prescribed after the first trimester for treatment of hypertension in pregnant women may interfere with normal plasma volume expansion and cause volume depletion. The authors hypothesized that prenatal exposure to diuretics and maternal hypertension might disrupt fetal neurodevelopment and increase the risk of schizophrenia in offspring.

METHOD

Using data from the Copenhagen Perinatal Cohort of individuals born between 1959 and 1961, the authors studied the relationship of maternal hypertension and diuretic treatment during pregnancy with the risk of schizophrenia (ICD-8 code 295) in the offspring. Prenatal medical information was linked to the Danish National Psychiatric Register. The effects of maternal hypertension and diuretic treatment were adjusted for the maternal history of schizophrenia, social status of the family breadwinner, mother's age, and concomitant drug treatment during pregnancy.

RESULTS

In a risk set of 7,866 individuals, 84 cases of schizophrenia were found (1.1% prevalence). Logistic multiple regression analysis identified the following independent risk factors: maternal hypertension (odds ratio=1.69 [95% CI=1.02-2.80]), diuretic treatment in the third trimester (odds ratio=2.55 [95% CI=1.21-5.37]), and maternal schizophrenia (odds ratio=11.12 [95% CI=4.60-29.91]). Prenatal exposure to both hypertension and diuretic treatment in the third trimester conferred a 4.01-fold (95% CI=1.41-11.40) elevated risk.

CONCLUSIONS

Children of mothers with hypertension in pregnancy plus diuretic treatment in the third trimester were at significantly increased risk of developing schizophrenia. In pregnancies complicated by hypertension, diuretics may interfere with aspects of fetal neurodevelopment and thus increase the vulnerability of offspring to the development of schizophrenia later in life.

Authors+Show Affiliations

Danish Epidemiology Science Center, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark. holgerjs@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12611826

Citation

Sørensen, Holger J., et al. "Do Hypertension and Diuretic Treatment in Pregnancy Increase the Risk of Schizophrenia in Offspring?" The American Journal of Psychiatry, vol. 160, no. 3, 2003, pp. 464-8.
Sørensen HJ, Mortensen EL, Reinisch JM, et al. Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia in offspring? Am J Psychiatry. 2003;160(3):464-8.
Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2003). Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia in offspring? The American Journal of Psychiatry, 160(3), pp. 464-8.
Sørensen HJ, et al. Do Hypertension and Diuretic Treatment in Pregnancy Increase the Risk of Schizophrenia in Offspring. Am J Psychiatry. 2003;160(3):464-8. PubMed PMID: 12611826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia in offspring? AU - Sørensen,Holger J, AU - Mortensen,Erik L, AU - Reinisch,June M, AU - Mednick,Sarnoff A, PY - 2003/3/4/pubmed PY - 2003/4/26/medline PY - 2003/3/4/entrez SP - 464 EP - 8 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 160 IS - 3 N2 - OBJECTIVE: Diuretics prescribed after the first trimester for treatment of hypertension in pregnant women may interfere with normal plasma volume expansion and cause volume depletion. The authors hypothesized that prenatal exposure to diuretics and maternal hypertension might disrupt fetal neurodevelopment and increase the risk of schizophrenia in offspring. METHOD: Using data from the Copenhagen Perinatal Cohort of individuals born between 1959 and 1961, the authors studied the relationship of maternal hypertension and diuretic treatment during pregnancy with the risk of schizophrenia (ICD-8 code 295) in the offspring. Prenatal medical information was linked to the Danish National Psychiatric Register. The effects of maternal hypertension and diuretic treatment were adjusted for the maternal history of schizophrenia, social status of the family breadwinner, mother's age, and concomitant drug treatment during pregnancy. RESULTS: In a risk set of 7,866 individuals, 84 cases of schizophrenia were found (1.1% prevalence). Logistic multiple regression analysis identified the following independent risk factors: maternal hypertension (odds ratio=1.69 [95% CI=1.02-2.80]), diuretic treatment in the third trimester (odds ratio=2.55 [95% CI=1.21-5.37]), and maternal schizophrenia (odds ratio=11.12 [95% CI=4.60-29.91]). Prenatal exposure to both hypertension and diuretic treatment in the third trimester conferred a 4.01-fold (95% CI=1.41-11.40) elevated risk. CONCLUSIONS: Children of mothers with hypertension in pregnancy plus diuretic treatment in the third trimester were at significantly increased risk of developing schizophrenia. In pregnancies complicated by hypertension, diuretics may interfere with aspects of fetal neurodevelopment and thus increase the vulnerability of offspring to the development of schizophrenia later in life. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/12611826/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.160.3.464?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -