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Isoflavonoid and lignan phytoestrogens as dietary biomarkers.
J Nutr 2003; 133 Suppl 3:956S-964SJN

Abstract

Isoflavones and lignans are biologically active plant-food constituents that have potential chemopreventive properties. Quantitation of isoflavones and lignans in humans is necessary to establish the benefits and risks of exposure to these compounds in populations and to determine which components of a mixed diet contribute to the exposure. Isoflavones and lignans are metabolized by colonic bacteria to more biologically active metabolites; thus both the parent compounds and the metabolites are measured routinely. Isoflavonoids (genistein, daidzein, dihydrodaidzein, O-desmethylangolensin and equol) and lignans (enterolactone, enterodiol, matairesinol and secoisolariciresinol) can be quantified in various body fluids. Typically, high concentrations of isoflavonoids in urine and serum are associated with soy consumption, and high concentrations of lignans are associated primarily with intake of whole grains and other fiber-containing plant foods. Controlled feeding studies and nutritional epidemiologic studies demonstrate a linear dose response between dietary intake and urinary excretion of isoflavones. Lignan excretion is associated positively with dietary fiber intake as well as with diets that are on average higher in fiber and carbohydrate and lower in fat; thus lignans have also been proposed as a marker of healthier dietary patterns. The complex interactions between the colonic environment and the external and internal factors that modulate it contribute to significant variation in serum and urinary phytoestrogen levels among individuals. Understanding these sources of variation is important to be able to use these measures effectively as dietary biomarkers.

Authors+Show Affiliations

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. jlampe@fhcrc.org

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12612182

Citation

Lampe, Johanna W.. "Isoflavonoid and Lignan Phytoestrogens as Dietary Biomarkers." The Journal of Nutrition, vol. 133 Suppl 3, 2003, 956S-964S.
Lampe JW. Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr. 2003;133 Suppl 3:956S-964S.
Lampe, J. W. (2003). Isoflavonoid and lignan phytoestrogens as dietary biomarkers. The Journal of Nutrition, 133 Suppl 3, 956S-964S. doi:10.1093/jn/133.3.956S.
Lampe JW. Isoflavonoid and Lignan Phytoestrogens as Dietary Biomarkers. J Nutr. 2003;133 Suppl 3:956S-964S. PubMed PMID: 12612182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavonoid and lignan phytoestrogens as dietary biomarkers. A1 - Lampe,Johanna W, PY - 2003/3/4/pubmed PY - 2003/4/11/medline PY - 2003/3/4/entrez SP - 956S EP - 964S JF - The Journal of nutrition JO - J. Nutr. VL - 133 Suppl 3 N2 - Isoflavones and lignans are biologically active plant-food constituents that have potential chemopreventive properties. Quantitation of isoflavones and lignans in humans is necessary to establish the benefits and risks of exposure to these compounds in populations and to determine which components of a mixed diet contribute to the exposure. Isoflavones and lignans are metabolized by colonic bacteria to more biologically active metabolites; thus both the parent compounds and the metabolites are measured routinely. Isoflavonoids (genistein, daidzein, dihydrodaidzein, O-desmethylangolensin and equol) and lignans (enterolactone, enterodiol, matairesinol and secoisolariciresinol) can be quantified in various body fluids. Typically, high concentrations of isoflavonoids in urine and serum are associated with soy consumption, and high concentrations of lignans are associated primarily with intake of whole grains and other fiber-containing plant foods. Controlled feeding studies and nutritional epidemiologic studies demonstrate a linear dose response between dietary intake and urinary excretion of isoflavones. Lignan excretion is associated positively with dietary fiber intake as well as with diets that are on average higher in fiber and carbohydrate and lower in fat; thus lignans have also been proposed as a marker of healthier dietary patterns. The complex interactions between the colonic environment and the external and internal factors that modulate it contribute to significant variation in serum and urinary phytoestrogen levels among individuals. Understanding these sources of variation is important to be able to use these measures effectively as dietary biomarkers. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/12612182/Isoflavonoid_and_lignan_phytoestrogens_as_dietary_biomarkers_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/133.3.956S DB - PRIME DP - Unbound Medicine ER -