Tags

Type your tag names separated by a space and hit enter

Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus.

Abstract

OBJECTIVE

Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2.

METHODS

Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review.

RESULTS

Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (beta=.38, P=.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (beta=.57, P=.002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry.

CONCLUSION

These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    University of Miami, Department of Psychology, Coral Gables, FL 33124, USA. dpereira@miami.edu

    , , , , , , , , ,

    Source

    Journal of psychosomatic research 54:3 2003 Mar pg 237-44

    MeSH

    Adolescent
    Adult
    Female
    HIV Infections
    Herpes Genitalis
    Humans
    Middle Aged
    Recurrence
    Regression Analysis
    Risk Factors
    Stress, Psychological

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12614833

    Citation

    Pereira, Deidre Byrnes, et al. "Stress as a Predictor of Symptomatic Genital Herpes Virus Recurrence in Women With Human Immunodeficiency Virus." Journal of Psychosomatic Research, vol. 54, no. 3, 2003, pp. 237-44.
    Pereira DB, Antoni MH, Danielson A, et al. Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus. J Psychosom Res. 2003;54(3):237-44.
    Pereira, D. B., Antoni, M. H., Danielson, A., Simon, T., Efantis-Potter, J., Carver, C. S., ... O'Sullivan, M. J. (2003). Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus. Journal of Psychosomatic Research, 54(3), pp. 237-44.
    Pereira DB, et al. Stress as a Predictor of Symptomatic Genital Herpes Virus Recurrence in Women With Human Immunodeficiency Virus. J Psychosom Res. 2003;54(3):237-44. PubMed PMID: 12614833.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus. AU - Pereira,Deidre Byrnes, AU - Antoni,Michael H, AU - Danielson,Aimee, AU - Simon,Trudi, AU - Efantis-Potter,JoNell, AU - Carver,Charles S, AU - Durán,Ron E F, AU - Ironson,Gail, AU - Klimas,Nancy, AU - Fletcher,Mary Ann, AU - O'Sullivan,Mary Jo, PY - 2003/3/5/pubmed PY - 2003/6/19/medline PY - 2003/3/5/entrez SP - 237 EP - 44 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 54 IS - 3 N2 - OBJECTIVE: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. METHODS: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. RESULTS: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (beta=.38, P=.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (beta=.57, P=.002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. CONCLUSION: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV. SN - 0022-3999 UR - https://www.unboundmedicine.com/medline/citation/12614833/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022399902004944 DB - PRIME DP - Unbound Medicine ER -