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Soluble adhesion molecules and myocardial injury during coronary artery bypass grafting.
World J Surg. 2003 Feb; 27(2):140-4.WJ

Abstract

Cardiopulmonary bypass is acknowledged to be one of the major causes of a complex systemic inflammatory response after cardiac surgery. Leukocyte-endothelial binding followed by neutrophil migration appears to play a central role. These interactions are mediated by adhesion molecules on the surface of activated cells. The present study compared the perioperative levels of soluble adhesion molecules after coronary artery bypass grafting (CABG) in patients with or without cardiopulmonary bypass (CPB). Altogether, 9 patients underwent off-pump revascularization and 11 did so with CPB. Plasma levels of soluble adhesion molecules sE-selectin and sP-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) were measured before anesthesia induction and 1, 4, and 20 hours after reperfusion to the myocardium. The baseline plasma levels of the adhesion molecules were similar in the two groups. Perioperative levels of sE-selectin remained the same and did not differ between groups. Plasma sP-selectin increased in both groups, the change being significantly greater in the CPB group than that in the off-pump group (p = 0.001). Plasma sICAM-1 decreased during an early stage after CABG with CPB, recovering at 4 hours after reperfusion; and a significant increase in ICAM-1 was observed 20 hours later. In the off-pump group, sICAM-1 levels did not change at 1 and 4 hours after reperfusion but increased 20 hours later. Postoperative creatine kinase-muscle bound (CK-MB) levels were significantly higher in the CPB group than in the off-pump group (p = 0.001). The change in sP-selectin levels also showed a correlation with CK-MB values (r = 0.676, p = 0.001). The results indicated that off-pump revascularization is associated with reduced endothelial activation and myocardial injury.

Authors+Show Affiliations

Division of Cardiothoracic Surgery, Tampere University Hospital, PO Box 2000, Fin-33521, Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12616425

Citation

Wei, Minxin, et al. "Soluble Adhesion Molecules and Myocardial Injury During Coronary Artery Bypass Grafting." World Journal of Surgery, vol. 27, no. 2, 2003, pp. 140-4.
Wei M, Kuukasjärvi P, Laurikka J, et al. Soluble adhesion molecules and myocardial injury during coronary artery bypass grafting. World J Surg. 2003;27(2):140-4.
Wei, M., Kuukasjärvi, P., Laurikka, J., Kaukinen, S., Iisalo, P., Laine, S., & Tarkka, M. (2003). Soluble adhesion molecules and myocardial injury during coronary artery bypass grafting. World Journal of Surgery, 27(2), 140-4.
Wei M, et al. Soluble Adhesion Molecules and Myocardial Injury During Coronary Artery Bypass Grafting. World J Surg. 2003;27(2):140-4. PubMed PMID: 12616425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble adhesion molecules and myocardial injury during coronary artery bypass grafting. AU - Wei,Minxin, AU - Kuukasjärvi,Pekka, AU - Laurikka,Jari, AU - Kaukinen,Seppo, AU - Iisalo,Pekka, AU - Laine,Seppo, AU - Tarkka,Matti, PY - 2003/3/5/pubmed PY - 2003/5/29/medline PY - 2003/3/5/entrez SP - 140 EP - 4 JF - World journal of surgery JO - World J Surg VL - 27 IS - 2 N2 - Cardiopulmonary bypass is acknowledged to be one of the major causes of a complex systemic inflammatory response after cardiac surgery. Leukocyte-endothelial binding followed by neutrophil migration appears to play a central role. These interactions are mediated by adhesion molecules on the surface of activated cells. The present study compared the perioperative levels of soluble adhesion molecules after coronary artery bypass grafting (CABG) in patients with or without cardiopulmonary bypass (CPB). Altogether, 9 patients underwent off-pump revascularization and 11 did so with CPB. Plasma levels of soluble adhesion molecules sE-selectin and sP-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) were measured before anesthesia induction and 1, 4, and 20 hours after reperfusion to the myocardium. The baseline plasma levels of the adhesion molecules were similar in the two groups. Perioperative levels of sE-selectin remained the same and did not differ between groups. Plasma sP-selectin increased in both groups, the change being significantly greater in the CPB group than that in the off-pump group (p = 0.001). Plasma sICAM-1 decreased during an early stage after CABG with CPB, recovering at 4 hours after reperfusion; and a significant increase in ICAM-1 was observed 20 hours later. In the off-pump group, sICAM-1 levels did not change at 1 and 4 hours after reperfusion but increased 20 hours later. Postoperative creatine kinase-muscle bound (CK-MB) levels were significantly higher in the CPB group than in the off-pump group (p = 0.001). The change in sP-selectin levels also showed a correlation with CK-MB values (r = 0.676, p = 0.001). The results indicated that off-pump revascularization is associated with reduced endothelial activation and myocardial injury. SN - 0364-2313 UR - https://www.unboundmedicine.com/medline/citation/12616425/Soluble_adhesion_molecules_and_myocardial_injury_during_coronary_artery_bypass_grafting_ L2 - https://dx.doi.org/10.1007/s00268-002-6595-y DB - PRIME DP - Unbound Medicine ER -