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Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks.
Nutr Metab Cardiovasc Dis. 2002 Oct; 12(5):291-5.NM

Abstract

BACKGROUND AND AIM

Replacing saturated fat with polyunsaturated fat reduces plasma cholesterol concentrations; however, it has not been well documented how rapidly the decline occurs nor how long is required to reach the maximum cholesterol-lowering effect. The aim of the present study was to determine the time course of change in plasma cholesterol concentrations when participants adopt a lipid-lowering diet.

METHODS AND RESULTS

Participants (n = 19) were asked to follow for 19 days a diet high in saturated fat and then crossed over--without washout--for 19 days to a diet high in n-6 polyunsaturated fat. Participants were asked to maintain a total fat intake of 30-33% of total energy on both diets. Energy and nutrient intakes were assessed by self-reported food records covering 3 days. Plasma total cholesterol concentrations were measured on days 0, 1, 2, 5, 8, 12, and 19 of the n-6 polyunsaturated fat rich diet. Mean (95% CI) plasma total cholesterol concentration declined from 5.10 mmol/L (4.77, 5.46) at day 0 to 4.25 mmol/L (3.83, 4.67) on day 12 and remained unchanged at 4.23 mmol/L (3.85, 4.61) on day 19. A statistically significant decrease in plasma cholesterol concentration was achieved on day 2 of the intervention; by day 5, 59% (0.51 mmol/L) of the maximum reduction (0.87 mmol/L) had been reached.

CONCLUSIONS

Adopting a lipid lowering diet initiates an immediate decline in plasma cholesterol concentration, the full effect of which is achieved within two weeks.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12616809

Citation

Hodson, L, et al. "Maximal Response to a Plasma Cholesterol-lowering Diet Is Achieved Within Two Weeks." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 12, no. 5, 2002, pp. 291-5.
Hodson L, Skeaff CM, McKenzie JE. Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks. Nutr Metab Cardiovasc Dis. 2002;12(5):291-5.
Hodson, L., Skeaff, C. M., & McKenzie, J. E. (2002). Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 12(5), 291-5.
Hodson L, Skeaff CM, McKenzie JE. Maximal Response to a Plasma Cholesterol-lowering Diet Is Achieved Within Two Weeks. Nutr Metab Cardiovasc Dis. 2002;12(5):291-5. PubMed PMID: 12616809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks. AU - Hodson,L, AU - Skeaff,C M, AU - McKenzie,J E, PY - 2003/3/6/pubmed PY - 2003/6/11/medline PY - 2003/3/6/entrez SP - 291 EP - 5 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 12 IS - 5 N2 - BACKGROUND AND AIM: Replacing saturated fat with polyunsaturated fat reduces plasma cholesterol concentrations; however, it has not been well documented how rapidly the decline occurs nor how long is required to reach the maximum cholesterol-lowering effect. The aim of the present study was to determine the time course of change in plasma cholesterol concentrations when participants adopt a lipid-lowering diet. METHODS AND RESULTS: Participants (n = 19) were asked to follow for 19 days a diet high in saturated fat and then crossed over--without washout--for 19 days to a diet high in n-6 polyunsaturated fat. Participants were asked to maintain a total fat intake of 30-33% of total energy on both diets. Energy and nutrient intakes were assessed by self-reported food records covering 3 days. Plasma total cholesterol concentrations were measured on days 0, 1, 2, 5, 8, 12, and 19 of the n-6 polyunsaturated fat rich diet. Mean (95% CI) plasma total cholesterol concentration declined from 5.10 mmol/L (4.77, 5.46) at day 0 to 4.25 mmol/L (3.83, 4.67) on day 12 and remained unchanged at 4.23 mmol/L (3.85, 4.61) on day 19. A statistically significant decrease in plasma cholesterol concentration was achieved on day 2 of the intervention; by day 5, 59% (0.51 mmol/L) of the maximum reduction (0.87 mmol/L) had been reached. CONCLUSIONS: Adopting a lipid lowering diet initiates an immediate decline in plasma cholesterol concentration, the full effect of which is achieved within two weeks. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/12616809/Maximal_response_to_a_plasma_cholesterol_lowering_diet_is_achieved_within_two_weeks_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -