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Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells.
Minerva Endocrinol. 2003 Mar; 28(1):53-73.ME

Abstract

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are potent regulators of muscle mass. Transgenic mice that over-express these proteins exhibit dramatically enlarged skeletal muscles. In contrast, malnutrition, critical illness, sepsis, and aging are all associated with a dramatic reduction in muscle mass and function. The circulating concentration of IGF-I and the expression of IGF-I in skeletal muscle are also reduced during catabolic states. Consequently, GH has been used clinically to increase lean body mass in patients with muscle wasting. Likewise, delivery of IGF-I specifically into muscle has been proposed as a genetic therapy for muscle disorders. A better understanding of the regulation of IGF-I expression in skeletal muscle and muscle cells is therefore of importance. Yet, our knowledge in this area has been limited by a lack of GH responsive muscle cells. In addition the IGF-I gene spans over 90 kb of genomic DNA and it exhibits a very complex regulatory pattern. This review will summarize our knowledge of the control of muscle mass by GH, IGF-I, anabolic steroids, exercise and other growth enhancing hormones. We will also highlight recent advances in the regulation of IGF-I and signal transducers and activators of transcription (Stats) by GH. A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells.

Authors+Show Affiliations

Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA 17033, USA. RFROST@PSU.EDUNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12621363

Citation

Frost, R A., and C H. Lang. "Regulation of Insulin-like Growth factor-I in Skeletal Muscle and Muscle Cells." Minerva Endocrinologica, vol. 28, no. 1, 2003, pp. 53-73.
Frost RA, Lang CH. Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. Minerva Endocrinol. 2003;28(1):53-73.
Frost, R. A., & Lang, C. H. (2003). Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. Minerva Endocrinologica, 28(1), 53-73.
Frost RA, Lang CH. Regulation of Insulin-like Growth factor-I in Skeletal Muscle and Muscle Cells. Minerva Endocrinol. 2003;28(1):53-73. PubMed PMID: 12621363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. AU - Frost,R A, AU - Lang,C H, PY - 2003/3/7/pubmed PY - 2003/6/17/medline PY - 2003/3/7/entrez SP - 53 EP - 73 JF - Minerva endocrinologica JO - Minerva Endocrinol. VL - 28 IS - 1 N2 - Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are potent regulators of muscle mass. Transgenic mice that over-express these proteins exhibit dramatically enlarged skeletal muscles. In contrast, malnutrition, critical illness, sepsis, and aging are all associated with a dramatic reduction in muscle mass and function. The circulating concentration of IGF-I and the expression of IGF-I in skeletal muscle are also reduced during catabolic states. Consequently, GH has been used clinically to increase lean body mass in patients with muscle wasting. Likewise, delivery of IGF-I specifically into muscle has been proposed as a genetic therapy for muscle disorders. A better understanding of the regulation of IGF-I expression in skeletal muscle and muscle cells is therefore of importance. Yet, our knowledge in this area has been limited by a lack of GH responsive muscle cells. In addition the IGF-I gene spans over 90 kb of genomic DNA and it exhibits a very complex regulatory pattern. This review will summarize our knowledge of the control of muscle mass by GH, IGF-I, anabolic steroids, exercise and other growth enhancing hormones. We will also highlight recent advances in the regulation of IGF-I and signal transducers and activators of transcription (Stats) by GH. A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells. SN - 0391-1977 UR - https://www.unboundmedicine.com/medline/citation/12621363/Regulation_of_insulin_like_growth_factor_I_in_skeletal_muscle_and_muscle_cells_ L2 - https://www.lens.org/lens/search?q=citation_id:12621363 DB - PRIME DP - Unbound Medicine ER -