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Glycaemic control by Casearia esculenta--a short duration study in albino rats.
Pharmazie. 2003 Jan; 58(1):49-52.P

Abstract

An aqueous extract of Casearia esculenta was found to lower blood glucose in basal conditions and after a glucose load in normal rats. Maximum reduction in blood glucose was observed between 2-3 h at a dose level of 200 and 300 mg/kg body weight. C. esculenta extract was also found to reduce the blood sugar level in streptozotocin--induced diabetic rats. Oral administration of the extract significantly reduced the blood sugar in streptozotocin induced diabetic rats for 15 days. The extract was also found to reduce the increased plasma thiobarbituric acid reactive substances (TBARS), blood urea and improvement in body weight reduction induced by streptozotocin injection. These results indicate that C. esculenta extracts are able to ameliorate biochemical changes induced by streptozotocin in diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12622253

Citation

Prakasam, A, et al. "Glycaemic Control By Casearia Esculenta--a Short Duration Study in Albino Rats." Die Pharmazie, vol. 58, no. 1, 2003, pp. 49-52.
Prakasam A, Sethupathy S, Pugalendi KV. Glycaemic control by Casearia esculenta--a short duration study in albino rats. Pharmazie. 2003;58(1):49-52.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2003). Glycaemic control by Casearia esculenta--a short duration study in albino rats. Die Pharmazie, 58(1), 49-52.
Prakasam A, Sethupathy S, Pugalendi KV. Glycaemic Control By Casearia Esculenta--a Short Duration Study in Albino Rats. Pharmazie. 2003;58(1):49-52. PubMed PMID: 12622253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycaemic control by Casearia esculenta--a short duration study in albino rats. AU - Prakasam,A, AU - Sethupathy,S, AU - Pugalendi,K V, PY - 2003/3/8/pubmed PY - 2003/4/10/medline PY - 2003/3/8/entrez SP - 49 EP - 52 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 1 N2 - An aqueous extract of Casearia esculenta was found to lower blood glucose in basal conditions and after a glucose load in normal rats. Maximum reduction in blood glucose was observed between 2-3 h at a dose level of 200 and 300 mg/kg body weight. C. esculenta extract was also found to reduce the blood sugar level in streptozotocin--induced diabetic rats. Oral administration of the extract significantly reduced the blood sugar in streptozotocin induced diabetic rats for 15 days. The extract was also found to reduce the increased plasma thiobarbituric acid reactive substances (TBARS), blood urea and improvement in body weight reduction induced by streptozotocin injection. These results indicate that C. esculenta extracts are able to ameliorate biochemical changes induced by streptozotocin in diabetic rats. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/12622253/Glycaemic_control_by_Casearia_esculenta__a_short_duration_study_in_albino_rats_ DB - PRIME DP - Unbound Medicine ER -