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Beef allergy: a review of 12 cases.
Allergy 2003; 58(2):127-31A

Abstract

BACKGROUND

Although beef allergy has long been considered a rare condition, the number of studies regarding the nature, epidemiology, and symptoms of beef allergy has been increasing. We aimed to describe the results of allergy work-up of 12 patients who have a convincing history of acute allergic symptoms following beef ingestion.

METHODS

Detailed histories of 10 children and two adult relatives were obtained and patients underwent skin prick tests with commercial beef extract, raw beef and cooked beef. Serum total and beef-specific IgE were measured. Labial, and in selected cases, open food challenges were undertaken.

RESULTS

Interestingly, the rate of family history of beef allergy was 67% (8/12). Three patients (two with commercial extract, and one with cooked beef) had positive skin test responses to beef. Ten (83%) patients had elevated serum IgE concentrations (median 316.5 kU/l, range 9-1321 kU/l) and the beef-specific IgE was positive in all patients (median 6.23 kUA/l, range 0.83-36.6 kUA/l). Labial food challenge was positive in four (30%) patients. Of the five patients who underwent open food challenges, three were positive and two tolerated the beef administered.

CONCLUSIONS

We conclude that skin prick tests do not accurately diagnose IgE-mediated sensitization to beef. Thus, patients with suspected beef allergy should be screened additionally for beef-specific IgE antibodies, and in selected cases oral food challenge should be carried out to verify the diagnosis.

Authors+Show Affiliations

Hacettepe University Faculty of Medicine, Department of Pediatric Allergy and Asthma, Ankara, Turkey.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

12622743

Citation

Orhan, F, and B E. Sekerel. "Beef Allergy: a Review of 12 Cases." Allergy, vol. 58, no. 2, 2003, pp. 127-31.
Orhan F, Sekerel BE. Beef allergy: a review of 12 cases. Allergy. 2003;58(2):127-31.
Orhan, F., & Sekerel, B. E. (2003). Beef allergy: a review of 12 cases. Allergy, 58(2), pp. 127-31.
Orhan F, Sekerel BE. Beef Allergy: a Review of 12 Cases. Allergy. 2003;58(2):127-31. PubMed PMID: 12622743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beef allergy: a review of 12 cases. AU - Orhan,F, AU - Sekerel,B E, PY - 2003/3/8/pubmed PY - 2003/7/26/medline PY - 2003/3/8/entrez SP - 127 EP - 31 JF - Allergy JO - Allergy VL - 58 IS - 2 N2 - BACKGROUND: Although beef allergy has long been considered a rare condition, the number of studies regarding the nature, epidemiology, and symptoms of beef allergy has been increasing. We aimed to describe the results of allergy work-up of 12 patients who have a convincing history of acute allergic symptoms following beef ingestion. METHODS: Detailed histories of 10 children and two adult relatives were obtained and patients underwent skin prick tests with commercial beef extract, raw beef and cooked beef. Serum total and beef-specific IgE were measured. Labial, and in selected cases, open food challenges were undertaken. RESULTS: Interestingly, the rate of family history of beef allergy was 67% (8/12). Three patients (two with commercial extract, and one with cooked beef) had positive skin test responses to beef. Ten (83%) patients had elevated serum IgE concentrations (median 316.5 kU/l, range 9-1321 kU/l) and the beef-specific IgE was positive in all patients (median 6.23 kUA/l, range 0.83-36.6 kUA/l). Labial food challenge was positive in four (30%) patients. Of the five patients who underwent open food challenges, three were positive and two tolerated the beef administered. CONCLUSIONS: We conclude that skin prick tests do not accurately diagnose IgE-mediated sensitization to beef. Thus, patients with suspected beef allergy should be screened additionally for beef-specific IgE antibodies, and in selected cases oral food challenge should be carried out to verify the diagnosis. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/12622743/Beef_allergy:_a_review_of_12_cases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=2003&volume=58&issue=2&spage=127 DB - PRIME DP - Unbound Medicine ER -