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Association of HLA-DR and type II collagen autoimmunity with Meniere's disease.
Tissue Antigens. 2003 Jan; 61(1):99-103.TA

Abstract

To investigate HLA-associated genetic susceptibility to Meniere's disease in relation to type II collagen (CII) autoimmunity status, HLA-DRB1 genotyping and ELISA measurement of anti-CII antibody were performed in 41 Korean patients with Meniere's disease. In the anti-CII positive subgroup (20%) of patients, the frequency of HLA-DRB1*0405 was significantly increased (uncorrected) compared with both controls (63% vs 16%) and anti-CII negative patients (63% vs 12%). In the anti-CII negative subgroup, HLA-DRB1*1201 was significantly increased (uncorrected) (27% vs 10%) and DRB1*13 was decreased (6% vs 24%) compared with controls; these alleles appeared to confer susceptibility and resistance to the development of the disease. Association of HLA-DRB1*0405 with anti-CII positive Meniere's disease in this study suggests that it shares a specific HLA-DR sequence, QRRAA, as a genetic susceptibility factor with the anti-CII positive rheumatoid arthritis. In conclusion, whilst type II collagen autoimmunity may have a partial role in Meniere's disease, different HLA-DR alleles may also be associated with either susceptibility or resistance to the development of the disease in relation to anti-CII antibody status.

Authors+Show Affiliations

Koo JW
Department of Otolaryngology, Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea.
Oh SH
No affiliation info available
Chang SO
No affiliation info available
Park MH
No affiliation info available
Lim MJ
No affiliation info available
Yoo TJ
No affiliation info available
Kim CS
No affiliation info available

MeSH

AdultAgedAllelesAutoantibodiesAutoimmunityCollagen Type IIFemaleGenetic Predisposition to DiseaseHLA-DR AntigensHLA-DRB1 ChainsHumansMaleMeniere DiseaseSerologic Tests

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12622783

Citation

Koo, J-W, et al. "Association of HLA-DR and Type II Collagen Autoimmunity With Meniere's Disease." Tissue Antigens, vol. 61, no. 1, 2003, pp. 99-103.
Koo JW, Oh SH, Chang SO, et al. Association of HLA-DR and type II collagen autoimmunity with Meniere's disease. Tissue Antigens. 2003;61(1):99-103.
Koo, J. W., Oh, S. H., Chang, S. O., Park, M. H., Lim, M. J., Yoo, T. J., & Kim, C. S. (2003). Association of HLA-DR and type II collagen autoimmunity with Meniere's disease. Tissue Antigens, 61(1), 99-103.
Koo JW, et al. Association of HLA-DR and Type II Collagen Autoimmunity With Meniere's Disease. Tissue Antigens. 2003;61(1):99-103. PubMed PMID: 12622783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of HLA-DR and type II collagen autoimmunity with Meniere's disease. AU - Koo,J-W, AU - Oh,S H, AU - Chang,S O, AU - Park,M H, AU - Lim,M J, AU - Yoo,T-J, AU - Kim,C S, PY - 2003/3/8/pubmed PY - 2003/10/18/medline PY - 2003/3/8/entrez SP - 99 EP - 103 JF - Tissue antigens JO - Tissue Antigens VL - 61 IS - 1 N2 - To investigate HLA-associated genetic susceptibility to Meniere's disease in relation to type II collagen (CII) autoimmunity status, HLA-DRB1 genotyping and ELISA measurement of anti-CII antibody were performed in 41 Korean patients with Meniere's disease. In the anti-CII positive subgroup (20%) of patients, the frequency of HLA-DRB1*0405 was significantly increased (uncorrected) compared with both controls (63% vs 16%) and anti-CII negative patients (63% vs 12%). In the anti-CII negative subgroup, HLA-DRB1*1201 was significantly increased (uncorrected) (27% vs 10%) and DRB1*13 was decreased (6% vs 24%) compared with controls; these alleles appeared to confer susceptibility and resistance to the development of the disease. Association of HLA-DRB1*0405 with anti-CII positive Meniere's disease in this study suggests that it shares a specific HLA-DR sequence, QRRAA, as a genetic susceptibility factor with the anti-CII positive rheumatoid arthritis. In conclusion, whilst type II collagen autoimmunity may have a partial role in Meniere's disease, different HLA-DR alleles may also be associated with either susceptibility or resistance to the development of the disease in relation to anti-CII antibody status. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/12622783/Association_of_HLA_DR_and_type_II_collagen_autoimmunity_with_Meniere's_disease_ DB - PRIME DP - Unbound Medicine ER -