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Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain.
Neuropharmacology. 2003 Feb; 44(2):264-74.N

Abstract

Recent behavioral and pharmacological research shows extensive interplay between cannabinoid and opioid neurochemical systems. Here we examined the neuroanatomical basis of this interaction using c-fos immunohistochemistry. We compared Fos immunoreactivity in groups of male albino Wistar rats treated with vehicle, Delta(9)-tetrahydrocannabinol (THC, 10 mg/kg, i.p.), naloxone (10 mg/kg, i.p.) or THC and naloxone in combination. Locomotor activity was depressed in both THC treatment groups and moderately inhibited in rats given naloxone alone. Results showed that naloxone inhibited THC-induced Fos immunoreactivity in several key brain regions including the ventral tegmental area, ventromedial and dorsomedial hypothalamus, central caudate-putamen and ventrolateral periaqueductal grey. Conversely, naloxone and THC had an additive effect on Fos immunoreactivity in the central nucleus of the amygdala, the bed nucleus of the stria terminalis (lateral division), the insular cortex, and the paraventricular nucleus of the thalamus. These findings complement earlier pharmacological results showing potent modulation of cannabinoid-induced analgesia, appetite and reward by opioids. The inhibitory effects of naloxone on THC-induced ventral tegmentum, hypothalamic and periaqueductal grey Fos expression point to these structures as key sites involved in cannabinoid-opioid interactions.

Authors+Show Affiliations

School of Psychology, University of New England, Armidale NSW 2351, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12623225

Citation

Allen, K V., et al. "Regional Differences in Naloxone Modulation of Delta(9)-THC Induced Fos Expression in Rat Brain." Neuropharmacology, vol. 44, no. 2, 2003, pp. 264-74.
Allen KV, McGregor IS, Hunt GE, et al. Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain. Neuropharmacology. 2003;44(2):264-74.
Allen, K. V., McGregor, I. S., Hunt, G. E., Singh, M. E., & Mallet, P. E. (2003). Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain. Neuropharmacology, 44(2), 264-74.
Allen KV, et al. Regional Differences in Naloxone Modulation of Delta(9)-THC Induced Fos Expression in Rat Brain. Neuropharmacology. 2003;44(2):264-74. PubMed PMID: 12623225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain. AU - Allen,K V, AU - McGregor,I S, AU - Hunt,G E, AU - Singh,M E, AU - Mallet,P E, PY - 2003/3/8/pubmed PY - 2003/4/4/medline PY - 2003/3/8/entrez SP - 264 EP - 74 JF - Neuropharmacology JO - Neuropharmacology VL - 44 IS - 2 N2 - Recent behavioral and pharmacological research shows extensive interplay between cannabinoid and opioid neurochemical systems. Here we examined the neuroanatomical basis of this interaction using c-fos immunohistochemistry. We compared Fos immunoreactivity in groups of male albino Wistar rats treated with vehicle, Delta(9)-tetrahydrocannabinol (THC, 10 mg/kg, i.p.), naloxone (10 mg/kg, i.p.) or THC and naloxone in combination. Locomotor activity was depressed in both THC treatment groups and moderately inhibited in rats given naloxone alone. Results showed that naloxone inhibited THC-induced Fos immunoreactivity in several key brain regions including the ventral tegmental area, ventromedial and dorsomedial hypothalamus, central caudate-putamen and ventrolateral periaqueductal grey. Conversely, naloxone and THC had an additive effect on Fos immunoreactivity in the central nucleus of the amygdala, the bed nucleus of the stria terminalis (lateral division), the insular cortex, and the paraventricular nucleus of the thalamus. These findings complement earlier pharmacological results showing potent modulation of cannabinoid-induced analgesia, appetite and reward by opioids. The inhibitory effects of naloxone on THC-induced ventral tegmentum, hypothalamic and periaqueductal grey Fos expression point to these structures as key sites involved in cannabinoid-opioid interactions. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/12623225/Regional_differences_in_naloxone_modulation_of_Delta_9__THC_induced_Fos_expression_in_rat_brain_ DB - PRIME DP - Unbound Medicine ER -