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Infectious keratitis after LASIK.
Ophthalmology. 2003 Mar; 110(3):503-10.O

Abstract

PURPOSE

To report the clinical course, management, and outcomes of culture-proven infectious keratitis in 15 eyes of 13 subjects after LASIK.

DESIGN

Retrospective, noncomparative, interventional case series.

PARTICIPANTS

Fifteen eyes of 13 subjects who underwent LASIK and developed culture-positive keratitis.

INTERVENTION

Infectious keratitis was encountered in the operative eyes between 1 day and 450 days. Cultures were obtained, and topical antibiotic therapy was administered in all cases. Some cases required flap lifting, irrigation, and soaking of the bed with antibiotics, flap amputation, or further surgical intervention.

MAIN OUTCOME MEASURES

Time periods from onset to diagnosis, from clinical diagnosis to clinical resolution, final acuities, microbiologic profiles, and medical and surgical interventions were reviewed.

RESULTS

Onset of symptoms of infection varied, depending on the infectious organism. Bacterial organisms tended to present earlier, whereas mycobacterial and fungal organisms had a later mean onset of presentation. Furthermore, the atypical organisms such as mycobacteria, fungus, and acanthamoeba also had a more delayed diagnosis, resulting in a prolonged disease course.

CONCLUSIONS

Infectious keratitis after LASIK is a potentially vision-threatening complication. Onset of symptoms varies depending on causative agents. Furthermore, atypical organisms in the interface or beneath the flap can pose both diagnostic and therapeutic dilemmas. Location in the interface can make it more difficult to culture the organisms and prevent adequate penetration of topical antibiotics.

Authors+Show Affiliations

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12623812

Citation

Karp, Carol L., et al. "Infectious Keratitis After LASIK." Ophthalmology, vol. 110, no. 3, 2003, pp. 503-10.
Karp CL, Tuli SS, Yoo SH, et al. Infectious keratitis after LASIK. Ophthalmology. 2003;110(3):503-10.
Karp, C. L., Tuli, S. S., Yoo, S. H., Vroman, D. T., Alfonso, E. C., Huang, A. H., Pflugfelder, S. C., & Culbertson, W. W. (2003). Infectious keratitis after LASIK. Ophthalmology, 110(3), 503-10.
Karp CL, et al. Infectious Keratitis After LASIK. Ophthalmology. 2003;110(3):503-10. PubMed PMID: 12623812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infectious keratitis after LASIK. AU - Karp,Carol L, AU - Tuli,Sonal S, AU - Yoo,Sonia H, AU - Vroman,David T, AU - Alfonso,Eduardo C, AU - Huang,Andrew H, AU - Pflugfelder,Stephen C, AU - Culbertson,William W, PY - 2003/3/8/pubmed PY - 2003/3/26/medline PY - 2003/3/8/entrez SP - 503 EP - 10 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 3 N2 - PURPOSE: To report the clinical course, management, and outcomes of culture-proven infectious keratitis in 15 eyes of 13 subjects after LASIK. DESIGN: Retrospective, noncomparative, interventional case series. PARTICIPANTS: Fifteen eyes of 13 subjects who underwent LASIK and developed culture-positive keratitis. INTERVENTION: Infectious keratitis was encountered in the operative eyes between 1 day and 450 days. Cultures were obtained, and topical antibiotic therapy was administered in all cases. Some cases required flap lifting, irrigation, and soaking of the bed with antibiotics, flap amputation, or further surgical intervention. MAIN OUTCOME MEASURES: Time periods from onset to diagnosis, from clinical diagnosis to clinical resolution, final acuities, microbiologic profiles, and medical and surgical interventions were reviewed. RESULTS: Onset of symptoms of infection varied, depending on the infectious organism. Bacterial organisms tended to present earlier, whereas mycobacterial and fungal organisms had a later mean onset of presentation. Furthermore, the atypical organisms such as mycobacteria, fungus, and acanthamoeba also had a more delayed diagnosis, resulting in a prolonged disease course. CONCLUSIONS: Infectious keratitis after LASIK is a potentially vision-threatening complication. Onset of symptoms varies depending on causative agents. Furthermore, atypical organisms in the interface or beneath the flap can pose both diagnostic and therapeutic dilemmas. Location in the interface can make it more difficult to culture the organisms and prevent adequate penetration of topical antibiotics. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/12623812/Infectious_keratitis_after_LASIK_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(02)01760-8 DB - PRIME DP - Unbound Medicine ER -