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[Current preclinical findings on substances against Parkinson's disease].
Nervenarzt. 2003 Mar; 74 Suppl 1:S2-6.N

Abstract

Striatal dopamine loss provides the premise for dopamine substitution in palliative therapy for Parkinson's disease (PD). This includes firstly L-dopa (L-3,4-dihydroxyphenylalanine, levodopa) and dopamine receptor agonists. Although this therapy has been demonstrated to induce marked clinical improvement in the early stages of PD, its use is limited in the long term by a loss of efficacy. In addition, most patients develop the "long-term L-dopa syndrome," which is characterized by a decrease in the control of Parkinsonian symptoms (decrease in the drug's effect) and the appearance of certain motor disturbances including episodes of akinetic freezing, debilitating dyskinesias, and on-off periods. The aim in developing new drugs is to achieve better therapeutic approaches. In the case of PD, the main strategies are to develop (1) alternatives to L-dopa therapy for alleviating the striatal dopamine deficit while avoiding or retarding the long-term L-dopa syndrome, (2) antidyskinetic approaches, and (3) neuroprotective drugs aimed at causal treatment of PD which is able to preserve the remaining dopaminergic neurones and to halt or at least retard the disease process. This article reviews new approaches for the treatment of PD and presents findings from our studies using a new experimental in vivo model of PD.

Authors+Show Affiliations

Klinische Neurochemie, Universitätsklinik für Psychiatrie und Psychotherapie, Würzburg. manfred.gerlach@mail.uni-wuerzburg.deNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

12624677

Citation

Gerlach, M, and P Riederer. "[Current Preclinical Findings On Substances Against Parkinson's Disease]." Der Nervenarzt, vol. 74 Suppl 1, 2003, pp. S2-6.
Gerlach M, Riederer P. [Current preclinical findings on substances against Parkinson's disease]. Nervenarzt. 2003;74 Suppl 1:S2-6.
Gerlach, M., & Riederer, P. (2003). [Current preclinical findings on substances against Parkinson's disease]. Der Nervenarzt, 74 Suppl 1, S2-6.
Gerlach M, Riederer P. [Current Preclinical Findings On Substances Against Parkinson's Disease]. Nervenarzt. 2003;74 Suppl 1:S2-6. PubMed PMID: 12624677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Current preclinical findings on substances against Parkinson's disease]. AU - Gerlach,M, AU - Riederer,P, PY - 2003/3/8/pubmed PY - 2003/8/29/medline PY - 2003/3/8/entrez SP - S2 EP - 6 JF - Der Nervenarzt JO - Nervenarzt VL - 74 Suppl 1 N2 - Striatal dopamine loss provides the premise for dopamine substitution in palliative therapy for Parkinson's disease (PD). This includes firstly L-dopa (L-3,4-dihydroxyphenylalanine, levodopa) and dopamine receptor agonists. Although this therapy has been demonstrated to induce marked clinical improvement in the early stages of PD, its use is limited in the long term by a loss of efficacy. In addition, most patients develop the "long-term L-dopa syndrome," which is characterized by a decrease in the control of Parkinsonian symptoms (decrease in the drug's effect) and the appearance of certain motor disturbances including episodes of akinetic freezing, debilitating dyskinesias, and on-off periods. The aim in developing new drugs is to achieve better therapeutic approaches. In the case of PD, the main strategies are to develop (1) alternatives to L-dopa therapy for alleviating the striatal dopamine deficit while avoiding or retarding the long-term L-dopa syndrome, (2) antidyskinetic approaches, and (3) neuroprotective drugs aimed at causal treatment of PD which is able to preserve the remaining dopaminergic neurones and to halt or at least retard the disease process. This article reviews new approaches for the treatment of PD and presents findings from our studies using a new experimental in vivo model of PD. SN - 0028-2804 UR - https://www.unboundmedicine.com/medline/citation/12624677/[Current_preclinical_findings_on_substances_against_Parkinson's_disease]_ DB - PRIME DP - Unbound Medicine ER -