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[Homocysteine and dementia].
Fortschr Neurol Psychiatr 2003; 71(3):150-6FN

Abstract

Homocysteine is a vascular risk factor including cerebral macroangiopathy and microangiopathy. Furthermore, there might also be an association with cognitive disorders including vascular dementia and Alzheimer's disease. Hyperhomocysteinemia linked with cognitive impairment might be an indirect marker for low concentrations of vitamin B 12, vitamin B 6 or folate, resulting from low intake or from an impaired transport of the vitamins to the brain. Another possibility is a direct harmful effect of homocysteine to cognition via vascular and neurotoxic pathophysiologic mechanisms. Because hyperhomocysteinemia is a potentially reversible risk factor and can be identified early, it should be investigated by prospective intervention studies whether lowering homocysteine levels by vitamin supplementation could reduce incidence and progression of cognitive disorders.

Authors+Show Affiliations

Universitäts-Nervenklinik und Poliklinik, Psychiatrie und Psychotherapie, Homburg/Saar. nehkes@uniklinik-saarland.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

12624852

Citation

Kessler, H, et al. "[Homocysteine and Dementia]." Fortschritte Der Neurologie-Psychiatrie, vol. 71, no. 3, 2003, pp. 150-6.
Kessler H, Bleich S, Falkai P, et al. [Homocysteine and dementia]. Fortschr Neurol Psychiatr. 2003;71(3):150-6.
Kessler, H., Bleich, S., Falkai, P., & Supprian, T. (2003). [Homocysteine and dementia]. Fortschritte Der Neurologie-Psychiatrie, 71(3), pp. 150-6.
Kessler H, et al. [Homocysteine and Dementia]. Fortschr Neurol Psychiatr. 2003;71(3):150-6. PubMed PMID: 12624852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Homocysteine and dementia]. AU - Kessler,H, AU - Bleich,S, AU - Falkai,P, AU - Supprian,T, PY - 2003/3/8/pubmed PY - 2003/5/8/medline PY - 2003/3/8/entrez SP - 150 EP - 6 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 71 IS - 3 N2 - Homocysteine is a vascular risk factor including cerebral macroangiopathy and microangiopathy. Furthermore, there might also be an association with cognitive disorders including vascular dementia and Alzheimer's disease. Hyperhomocysteinemia linked with cognitive impairment might be an indirect marker for low concentrations of vitamin B 12, vitamin B 6 or folate, resulting from low intake or from an impaired transport of the vitamins to the brain. Another possibility is a direct harmful effect of homocysteine to cognition via vascular and neurotoxic pathophysiologic mechanisms. Because hyperhomocysteinemia is a potentially reversible risk factor and can be identified early, it should be investigated by prospective intervention studies whether lowering homocysteine levels by vitamin supplementation could reduce incidence and progression of cognitive disorders. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/12624852/[Homocysteine_and_dementia]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-37755 DB - PRIME DP - Unbound Medicine ER -