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The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear.
Hippocampus. 2003; 13(1):53-8.H

Abstract

Pavlovian conditioning involves the association of initially neutral conditioned stimuli (CS) with unconditioned stimuli (US) that elicit a response. In contextual fear conditioning in rodents, the CS is the context of a training apparatus and the US is a foot shock. Retrieval of memory of the training is tested by presenting the CS alone. But a retrieval test also initiates extinction of the conditioned response. That is, presentation of the CS alone results in new learning, i.e., the CS no longer predicts the US. Here we report that extinction is triggered by two hippocampal signaling pathways underlying retrieval (the cAMP-dependent protein kinase and the mitogen-activated protein kinase pathways) and two other mechanisms that become activated at the same time and are not necessary for retrieval (N-methyl-D-aspartate glutamatergic receptors and the calcium/calmodulin-dependent protein kinase II signaling pathway). Thus, the molecular mechanisms underlying acquisition and/or consolidation of the memory for extinction are similar to those described for the acquisition and/or consolidation of the original contextual fear.

Authors+Show Affiliations

Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12625457

Citation

Szapiro, German, et al. "The Role of NMDA Glutamate Receptors, PKA, MAPK, and CAMKII in the Hippocampus in Extinction of Conditioned Fear." Hippocampus, vol. 13, no. 1, 2003, pp. 53-8.
Szapiro G, Vianna MR, McGaugh JL, et al. The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Hippocampus. 2003;13(1):53-8.
Szapiro, G., Vianna, M. R., McGaugh, J. L., Medina, J. H., & Izquierdo, I. (2003). The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Hippocampus, 13(1), 53-8.
Szapiro G, et al. The Role of NMDA Glutamate Receptors, PKA, MAPK, and CAMKII in the Hippocampus in Extinction of Conditioned Fear. Hippocampus. 2003;13(1):53-8. PubMed PMID: 12625457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. AU - Szapiro,German, AU - Vianna,Monica R M, AU - McGaugh,James L, AU - Medina,Jorge H, AU - Izquierdo,Ivan, PY - 2003/3/11/pubmed PY - 2003/4/19/medline PY - 2003/3/11/entrez SP - 53 EP - 8 JF - Hippocampus JO - Hippocampus VL - 13 IS - 1 N2 - Pavlovian conditioning involves the association of initially neutral conditioned stimuli (CS) with unconditioned stimuli (US) that elicit a response. In contextual fear conditioning in rodents, the CS is the context of a training apparatus and the US is a foot shock. Retrieval of memory of the training is tested by presenting the CS alone. But a retrieval test also initiates extinction of the conditioned response. That is, presentation of the CS alone results in new learning, i.e., the CS no longer predicts the US. Here we report that extinction is triggered by two hippocampal signaling pathways underlying retrieval (the cAMP-dependent protein kinase and the mitogen-activated protein kinase pathways) and two other mechanisms that become activated at the same time and are not necessary for retrieval (N-methyl-D-aspartate glutamatergic receptors and the calcium/calmodulin-dependent protein kinase II signaling pathway). Thus, the molecular mechanisms underlying acquisition and/or consolidation of the memory for extinction are similar to those described for the acquisition and/or consolidation of the original contextual fear. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/12625457/The_role_of_NMDA_glutamate_receptors_PKA_MAPK_and_CAMKII_in_the_hippocampus_in_extinction_of_conditioned_fear_ L2 - https://doi.org/10.1002/hipo.10043 DB - PRIME DP - Unbound Medicine ER -