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The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes.
Gynecol Endocrinol 2002; 16(6):453-60GE

Abstract

The contribution of the tumor necrosis factor (TNF) system and leptin was studied in insulin resistance and neonatal development during the course of normal pregnancy and gestational diabetes mellitus (GDM). Thirty patients with GDM and their neonates (n = 30), 35 healthy pregnant women (15 in the first, nine in the second and 11 in the third trimester) and their neonates (n = 20), and 25 healthy matched non-pregnant women participated in the study. Significantly elevated levels of maternal TNF-alpha, sTNF receptor (R)-1 and R-2, leptin (detected by enzyme-linked immunosorbent assay) and fasting C-peptide (measured by radioimmunossay and raised body mass index (BMI) were found in GDM patients and in the third trimester of normal pregnancies. TNF-alpha, sTNFR-2, C-peptide, leptin concentrations and BMI positively correlated with each other in GDM. An inverse relationship between the body length, head circumference and body weight of the newborns, and maternal TNF-alpha, leptin and C-peptide concentrations was shown in GDM. In healthy pregnancies the maternal serum leptin level was in a negative linear correlation with the head circumference of the newborns. In conclusion, increased TNF-alpha and leptin levels may contribute to insulin resistance in GDM and in the third trimester of normal pregnancy and may negatively influence the anthropometric parameters of the newborns.

Authors+Show Affiliations

Károlyi Hospital, Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12626032

Citation

Cseh, K, et al. "The Pathophysiological Influence of Leptin and the Tumor Necrosis Factor System On Maternal Insulin Resistance: Negative Correlation With Anthropometric Parameters of Neonates in Gestational Diabetes." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 16, no. 6, 2002, pp. 453-60.
Cseh K, Baranyi E, Melczer Z, et al. The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecol Endocrinol. 2002;16(6):453-60.
Cseh, K., Baranyi, E., Melczer, Z., Csákány, G. M., Speer, G., Kovács, M., ... Winkler, G. (2002). The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 16(6), pp. 453-60.
Cseh K, et al. The Pathophysiological Influence of Leptin and the Tumor Necrosis Factor System On Maternal Insulin Resistance: Negative Correlation With Anthropometric Parameters of Neonates in Gestational Diabetes. Gynecol Endocrinol. 2002;16(6):453-60. PubMed PMID: 12626032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. AU - Cseh,K, AU - Baranyi,E, AU - Melczer,Z, AU - Csákány,G M, AU - Speer,G, AU - Kovács,M, AU - Gerö,G, AU - Karádi,I, AU - Winkler,G, PY - 2003/3/11/pubmed PY - 2003/6/28/medline PY - 2003/3/11/entrez SP - 453 EP - 60 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 16 IS - 6 N2 - The contribution of the tumor necrosis factor (TNF) system and leptin was studied in insulin resistance and neonatal development during the course of normal pregnancy and gestational diabetes mellitus (GDM). Thirty patients with GDM and their neonates (n = 30), 35 healthy pregnant women (15 in the first, nine in the second and 11 in the third trimester) and their neonates (n = 20), and 25 healthy matched non-pregnant women participated in the study. Significantly elevated levels of maternal TNF-alpha, sTNF receptor (R)-1 and R-2, leptin (detected by enzyme-linked immunosorbent assay) and fasting C-peptide (measured by radioimmunossay and raised body mass index (BMI) were found in GDM patients and in the third trimester of normal pregnancies. TNF-alpha, sTNFR-2, C-peptide, leptin concentrations and BMI positively correlated with each other in GDM. An inverse relationship between the body length, head circumference and body weight of the newborns, and maternal TNF-alpha, leptin and C-peptide concentrations was shown in GDM. In healthy pregnancies the maternal serum leptin level was in a negative linear correlation with the head circumference of the newborns. In conclusion, increased TNF-alpha and leptin levels may contribute to insulin resistance in GDM and in the third trimester of normal pregnancy and may negatively influence the anthropometric parameters of the newborns. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/12626032/The_pathophysiological_influence_of_leptin_and_the_tumor_necrosis_factor_system_on_maternal_insulin_resistance:_negative_correlation_with_anthropometric_parameters_of_neonates_in_gestational_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -