Tags

Type your tag names separated by a space and hit enter

Soluble adhesion molecules in coronary surgery and cardiopulmonary bypass with pump prime aprotinin.
Scand Cardiovasc J. 2002 Dec; 36(6):345-9.SC

Abstract

OBJECTIVE

The purpose of the present study was to establish whether pump prime aprotinin could influence soluble adhesion molecules in patients undergoing elective coronary artery bypass surgery.

DESIGN

Thirty patients admitted for first-time elective coronary artery bypass surgery were randomized into control or aprotinin groups. Patients in the aprotinin group received 280 mg of aprotinin in the pump prime. Plasma levels of soluble adhesion molecules were analyzed perioperatively.

RESULTS

There were no significant changes in plasma sE-selectin after the operation in either group. Plasma sP-selectin increased significantly up to 20 h after reperfusion to the myocardium. Plasma sICAM-1 decreased in the early stage after cardiopulmonary bypass (CPB), then recovered at 4 h after reperfusion and a significant increase in sICAM-1 was observed 20 h later. There were no significant differences between the groups in postoperative changes in sP-selectin (p = 0.21) and sICAM-1 (p = 0.91).

CONCLUSION

Pump prime aprotinin did not influence plasma levels of E-selectin, P-selectin and ICAM-1 in the present patients. The present results do not support the concept of an anti-inflammatory effect of pump prime aprotinin.

Authors+Show Affiliations

Division of Cardiothoracic Surgery, Tampere University Hospital, FI-33521 Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12626201

Citation

Wei, Minxin, et al. "Soluble Adhesion Molecules in Coronary Surgery and Cardiopulmonary Bypass With Pump Prime Aprotinin." Scandinavian Cardiovascular Journal : SCJ, vol. 36, no. 6, 2002, pp. 345-9.
Wei M, Laurikka J, Kuukasjärvi P, et al. Soluble adhesion molecules in coronary surgery and cardiopulmonary bypass with pump prime aprotinin. Scand Cardiovasc J. 2002;36(6):345-9.
Wei, M., Laurikka, J., Kuukasjärvi, P., Pehkonen, E., Kaukinen, S., Laine, S., & Tarkka, M. (2002). Soluble adhesion molecules in coronary surgery and cardiopulmonary bypass with pump prime aprotinin. Scandinavian Cardiovascular Journal : SCJ, 36(6), 345-9.
Wei M, et al. Soluble Adhesion Molecules in Coronary Surgery and Cardiopulmonary Bypass With Pump Prime Aprotinin. Scand Cardiovasc J. 2002;36(6):345-9. PubMed PMID: 12626201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble adhesion molecules in coronary surgery and cardiopulmonary bypass with pump prime aprotinin. AU - Wei,Minxin, AU - Laurikka,Jari, AU - Kuukasjärvi,Pekka, AU - Pehkonen,Erkki, AU - Kaukinen,Seppo, AU - Laine,Seppo, AU - Tarkka,Matti, PY - 2003/3/11/pubmed PY - 2003/6/10/medline PY - 2003/3/11/entrez SP - 345 EP - 9 JF - Scandinavian cardiovascular journal : SCJ JO - Scand Cardiovasc J VL - 36 IS - 6 N2 - OBJECTIVE: The purpose of the present study was to establish whether pump prime aprotinin could influence soluble adhesion molecules in patients undergoing elective coronary artery bypass surgery. DESIGN: Thirty patients admitted for first-time elective coronary artery bypass surgery were randomized into control or aprotinin groups. Patients in the aprotinin group received 280 mg of aprotinin in the pump prime. Plasma levels of soluble adhesion molecules were analyzed perioperatively. RESULTS: There were no significant changes in plasma sE-selectin after the operation in either group. Plasma sP-selectin increased significantly up to 20 h after reperfusion to the myocardium. Plasma sICAM-1 decreased in the early stage after cardiopulmonary bypass (CPB), then recovered at 4 h after reperfusion and a significant increase in sICAM-1 was observed 20 h later. There were no significant differences between the groups in postoperative changes in sP-selectin (p = 0.21) and sICAM-1 (p = 0.91). CONCLUSION: Pump prime aprotinin did not influence plasma levels of E-selectin, P-selectin and ICAM-1 in the present patients. The present results do not support the concept of an anti-inflammatory effect of pump prime aprotinin. SN - 1401-7431 UR - https://www.unboundmedicine.com/medline/citation/12626201/Soluble_adhesion_molecules_in_coronary_surgery_and_cardiopulmonary_bypass_with_pump_prime_aprotinin_ DB - PRIME DP - Unbound Medicine ER -