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Different approaches to define individual amino acid requirements.

Abstract

A full review of the strengths and limitations of the various methods used to define amino acid requirements is provided. The focus is on the recent development of carbon oxidation techniques such as indicator amino acid oxidation and 24-h amino acid balance to determine dietary indispensable (essential) amino acid needs in adults. All approaches depend on the change in a metabolic parameter in response to graded intake of the test amino acid. In humans, the within-subject variance is less than the between-subject variance, which has led to an appreciation of the need to study each subject across a range of intakes, above and below the mean requirement level. The data can then be analyzed using two-phase linear regression crossover and a precise population mean requirement can be determined. Several approaches have been used to define the variance of the mean requirement. Finally, a minimally invasive indicator amino acid oxidation model has been developed which allows the determination of dietary essential amino acid requirements in children and other vulnerable populations.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada. paul.pencharz@sickkids.ca

    Source

    Annual review of nutrition 23: 2003 pg 101-16

    MeSH

    Amino Acids, Essential
    Carbon Isotopes
    Cross-Over Studies
    Humans
    Linear Models
    Nutrition Assessment
    Nutritional Requirements
    Oxidation-Reduction

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12626690

    Citation

    Pencharz, Paul B., and Ronald O. Ball. "Different Approaches to Define Individual Amino Acid Requirements." Annual Review of Nutrition, vol. 23, 2003, pp. 101-16.
    Pencharz PB, Ball RO. Different approaches to define individual amino acid requirements. Annu Rev Nutr. 2003;23:101-16.
    Pencharz, P. B., & Ball, R. O. (2003). Different approaches to define individual amino acid requirements. Annual Review of Nutrition, 23, pp. 101-16.
    Pencharz PB, Ball RO. Different Approaches to Define Individual Amino Acid Requirements. Annu Rev Nutr. 2003;23:101-16. PubMed PMID: 12626690.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Different approaches to define individual amino acid requirements. AU - Pencharz,Paul B, AU - Ball,Ronald O, Y1 - 2003/02/21/ PY - 2003/3/11/pubmed PY - 2003/11/11/medline PY - 2003/3/11/entrez SP - 101 EP - 16 JF - Annual review of nutrition JO - Annu. Rev. Nutr. VL - 23 N2 - A full review of the strengths and limitations of the various methods used to define amino acid requirements is provided. The focus is on the recent development of carbon oxidation techniques such as indicator amino acid oxidation and 24-h amino acid balance to determine dietary indispensable (essential) amino acid needs in adults. All approaches depend on the change in a metabolic parameter in response to graded intake of the test amino acid. In humans, the within-subject variance is less than the between-subject variance, which has led to an appreciation of the need to study each subject across a range of intakes, above and below the mean requirement level. The data can then be analyzed using two-phase linear regression crossover and a precise population mean requirement can be determined. Several approaches have been used to define the variance of the mean requirement. Finally, a minimally invasive indicator amino acid oxidation model has been developed which allows the determination of dietary essential amino acid requirements in children and other vulnerable populations. SN - 0199-9885 UR - https://www.unboundmedicine.com/medline/citation/12626690/full_citation L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev.nutr.23.011702.073247?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -